CAS: 769-40-4; 2,3,5,6-Tetrafluorothiophenol

该化合物是一种含分子式C6H2F4S的氟芳烃硫醇.其主要优点包括作为硫醇衍生物的高度再活性,使其在核生殖替代和金属协调化学中具有价值.四氟芳香环会增强电子提取特性,提高合成应用的稳定性和选择性.该化合物对于准备氟离心,制药和农用化学中间体特别有用.其低挥发性和强力硫磺的再活性可以有效地融入复杂的分子框架.氟基次成分也有助于增加亲脂性,这在物质科学和药用化学应用中可能具有优势.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号363-72-4 五氟苯 | CAS号327-54-8 1,2,4,5-四氟苯 | CAS号111873-88-2 (2,3,5,6-tetraf... | CAS号1559-88-2 1-溴-2,3,5,6-四氟苯 | CAS号344-04-7 溴五氟苯 | CAS号1835-61-6 3-氯-1,2,4,5-四氟苯 | CAS号5211-44-9 2,3,5,6-四氟-4-巯基苯甲酸

合成工艺路线路线简述

    📜1,2,4,5-四氟苯 反应生成 2,3,5,6-四氟苯硫酚
    参考文献:部分氟化的杂环化合物.第二部分 通过新的环化反应制备4,5,6,7-四氟苯并[B]噻吩
    标题:部分氟化的杂环化合物.第二部分 通过新的环化反应制备4,5,6,7-四氟苯并[B]噻吩
    摘要:通过新的一步式环化反应,五氟苯硫基磺酸根离子与乙酰二羧酸乙酯的反应得到了4,5,6,7-四氟苯并[B]噻吩的衍生物.提出了通过常规环化反应对该环系统的其他合成方法.
    DOI:10.1039/j39670000865

    专利信息


    专利号:US-10150160-B2
    优先权日:2014-12-04
    标题 :Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles
    发明人：PAZOS PÉREZ NICOLÃ?S; MIR DE SIMÓN BERNAT
    权利人:MEDCOM ADVANCE S A; MEDCOM ADVANCE S A
    摘要:The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.

    专利号:US-2017326638-A1
    优先权日:2014-12-04
    标 题:Universal one-pot and up-scalable synthesis of sers encoded nanoparticles

    专利号:EP-3227037-A1
    优先权日:2014-12-04
    标 题:Universal one-pot and up-scalable synthesis of sers encoded nanoparticles

    专利号:EP-3227037-B1
    优先权日:2014-12-04
    标题 :Universal one-pot and up-scalable synthesis of sers encoded nanoparticles

    专利号:ES-2673013-T3
    优先权日:2014-12-04
    标题:Universal synthesis of a single, large-scale, realizable reaction of nanoparticles encoded with SERS

    专利号:WO-2016086999-A1
    优先权日:2014-12-04
    标 题:Universal one-pot and up-scalable synthesis of sers encoded nanoparticles

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: L Embree, Et Al. Gas-Chromatographic Analysis Of Busulfan For Therapeutic Drug Monitoring. Cancer Chemother Pharmacol. 1993;32(2):137-42.
    [参考文献]: M H Quernin, Et Al. Quantification Of Busulfan In Plasma By Gas Chromatography-Mass Spectrometry Following Derivatization With Tetrafluorothiophenol. J Chromatogr B Biomed Sci Appl. 1998 May 8;709(1):47-56.
    [参考文献]: R B Burns, Et Al. A Gas-Chromatographic Assay Method For Busulfan With Sensitivity For Test Dose Therapeutic Monitoring. J Pharm Biomed Anal. 1995 Aug;13(9):1073-8.

    合成参考文献


    摘要:Beier, P., Science of Synthesis Knowledge Updates, (2014) 2, 315.
    参考文献:10.1016/s0021-9673(01)00998-0
    摘要:Newman JW, Hammock BD. Optimized thiol derivatizing reagent for the mass spectral analysis of disubstituted epoxy fatty acids. J Chromatogr A. 2001 Aug 03;925(1-2):223–40. doi: 10.1016/s0021-9673(01)00998-0.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知