CAS: 76-66-4; Rhynchophylline
- 英文名称Rhynchophylline
- 中文名称钩藤碱
- IUPAC名称(αE,1′R,6′R,7′S,8′aS)-6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, methyl ester
- 其它别名Methyl (E)-2-[(6'R,7'S)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
- CAS编号76-66-4
- MFCD编号:MFCD00221748
- EINECS号:683-092-0
- FDA UNII编号:46BQ79VJ8D
- 分子式:C22H28N2O4
- 分子量:384.47
- 产品CID: 1759092
- 产品分类生物化工 → 植物提取物
- 相似结构搜索
- 产品信息参考
; - InChIKey: DAXYUDFNWXHGBE-KAXDATADSA-N
- DAXYUDFNWXHGBE-QCJVZUPCSA-N…
- 计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数5.0
物理性质
- 熔点216°; mp 197-199° (Ban et al., loc. cit.)
- 沸点560.8±50.0 °C at 760 mmHg
- 闪点293.0±30.1 °C
- 密度1.2±0.1 g/cm3
- PH:D13 -14.7° (c = 2.5 in chloroform)
- pKa:6.4(at 25°C)
- PSA:67.87
- LogP:3.31
- 折射率1.596
- 蒸汽压0.0±1.5 mmHg at 25°C
- 溶解性Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- 外观形态白色至类白色固体
- 储存条件密封干燥,冷冻保存, 低于 -20°C
- 产品应用该化合物是一种在U. RHYNCOPHYLLA发现并具有多种生物活动的ALKALOIDAL,
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号630-94-4 去氢钩藤碱 | CAS号61-54-1 色胺 | CAS号1443767-65-4 tert-butyl 2,5-...合成工艺路线路线简述
海关参考信息
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专利信息
专利号:US-2025092433-A1
优先权日:2023-09-20
标 题:Polypeptides for use in the synthesis of kratom alkaloids
发明人：CASARETTO JOSE; AKTAR TARIQ A; ROTHSTEIN STEVEN; SOUBEYRAND ERIC
权利人:MITRADYNE CORP
摘要:Described herein are polypeptides encoding enzymes for the synthesis of monoterpene indole alkaloids. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1-68, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1-68, or a fragment of the polypeptide, or the variant thereof.
专利号:US-9604987-B2
优先权日:2011-03-23
标题 :Synthesis of autophagy inducing compound and the uses thereof
发明人：LI MIN; Liu liang feng; SONG JU XIAN; Zhang hong jie
权利人:UNIV HONG KONG BAPTIST UNIV
摘要:The present invention relates to a composition comprising compound of formula CB6 or CB8, n nthe pharmaceutically-acceptable carrier, solvent, the salts thereof or a combination thereof which is used to treat autophagy-associated diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, etc. The present invention also relates to a method of treating these diseases by administering a therapeutically-effective amount of the compound to the subject in need of the treatment. The present invention further relates to the use of this compound in preparation of the composition to treat the diseases.
专利号:EP-4538367-A2
优先权日:2023-09-20
标 题:Polypeptides for use in the synthesis of kratom alkaloids
专利号:US-2016046629-A1
优先权日:2011-03-23
标题:Synthesis of autophagy inducing compound and the uses thereof
专利号:CN-108707101-B
优先权日:2018-07-05
标题:Method for photocatalytic synthesis of alkaloid
专利号:CN-108017637-A
优先权日:2017-12-21
标 题:A kind of indolopyrroloquinoline compound and its synthesis method
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主要参考文献
1: Wang L, Li H, Zhang H, Song X, Jiang H, Wang D, Wang Y. Serum-based metabolomics reveals the mechanism of action of isorhynchophylline in the intervention of atherosclerosis in ApoE-/- mice. Anal Methods. 2024 Feb 15;16(7):1083-1092. doi: 10.1039/d3ay01803b.
2024:5513141. doi: 10.1155/2024/5513141.
3: Wu Y, Bian Y, Fei J, Huang Y. Isorhynchophylline attenuates proliferation and migration of synovial fibroblasts via the FOXC1/β-catenin axis. Autoimmunity. 2023 Dec;56(1):2289868. doi: 10.1080/08916934.2023.2289868. Epub 2023 Dec 6. 24(22):16330. doi: 10.3390/ijms242216330.
合成参考文献
摘要:Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology., 94(17), 1989 []
摘要:Shi JS, Kenneth HG. Effect of rhynchophylline on apoptosis induced by dopamine in NT2 cells. Acta Pharmacol Sin. 2002 May;23(5):445–9.
参考文献:10.1002/bmc.3206
摘要:Lee CJ, Hsueh TY, Lin LC, Tsai TH. Determination of protein-unbound rhynchiphylline brain distribution by microdialysis and ultra-performance liquid chromatography with tandem mass spectrometry. Biomed Chromatogr. 2014 Jun;28(6):901–6. doi: 10.1002/bmc.3206.
参考文献:10.1007/s12640-019-00079-x
摘要:Long H, Ruan J, Zhang M, Wang C, Huang Y. Rhynchophylline Attenuates Tourette Syndrome via BDNF/NF-κB Pathway In Vivo and In Vitro. Neurotox Res. 2019 Nov;36(4):756–63. doi: 10.1007/s12640-019-00079-x.
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