CAS: 7451-76-5; (S)-2-(2-(2-Aminoacetamido)Acetamido)-3-(1H-Imidazol-4-yl)Propanoic Acid

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39145-52-3 305-84-0 3253-17-6

上下游产品

N-(fluoren-9-ylmethoxycarbonyl)glycine (9-fluorenylmethoxycarbonyl)-L-histidineCu(H-2 glycylglycyl-L-histidine)(1-) GH glycine glycylglycine

📜FmOC-甘氨酸,N-芴甲氧羰基-L-组氨酸 在 1-羟基苯并三唑,O-(Benzotriazol-1-yl)-N,N,N',N'-Tetramethyluronium Tetrafluoroborate,N,N-二异丙基乙胺,哌啶体系中,用 N-甲基吡咯烷酮,N,N-二甲基甲酰胺作为反应溶剂,反应 0.22H,获得 Glycyl-Glycyl-L-Histidine
参考文献:在序列选择性发光受体中利用可逆铜(II)肽配位.
标题:在序列选择性发光受体中利用可逆铜(II)肽配位.
摘要:尽管可以获得有关氨基酸和肽与金属离子的配位能力的大量信息,但在选择性肽受体的合理设计中很少使用这种信息.我们将铜(II)次氮基三乙酸根(Nta)配合物与对铵离子敏感的发光苯并冠醚结合在一起.该化合物显示了对含甘氨酸和组氨酸的序列的微摩尔亲和力和选择性,与铜(II)离子肽结合的序列非常相似:铜(II)Nta络合物的两个自由配位点与咪唑和氨基氮原子结合,复制非复合铜离子的初始配位步骤.苯并冠醚在分子内识别n端氨基部分,并且发射强度的显着增加表明结合事件,因为只有在事先进行了肽的配位后,分子内的铵离子-苯并冠醚之间的相互作用才能在水中产生足够的强度,从而触发发射信号.没有观察到分子间铵离子-苯并冠醚的结合.等温滴定热量法证实了从发射滴定得出的结合常数.因此,如从肽配位研究中推论出的,截短的铜(II)配位球和发光的苯并冠状醚的组合可以更合理地设计序列选择性肽受体.等温滴定热量法证实了从发射滴定得出
Doi:10.1002/Chem.200701442

专利信息

专利号:US-12024731-B2
优先权日:2017-05-03
标 题 :Methods and enzyme catalysts for the synthesis of non-canonical amino acids
发明人：BOVILLE CHRISTINA E; BRINKMANN-CHEN SABINE; BULLER ANDREW R; ROMNEY DAVID K; PRIER CHRISTOPHER K; KOCH PHILIPP; SCHEELE REMKES A
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.

专利号:US-2022340947-A1
优先权日:2011-11-04
标题 :Prokaryote-based cell-free system for the synthesis of glycoproteins

专利号:CN-115916995-A
优先权日:2020-05-13
标题:Efficient synthesis of omega-glycosides and alkyl glycosides

专利号:US-9751911-B2
优先权日:2012-11-27
标 题:Solomonamide analogue compounds, pharmaceuticals containing solomonamide analogue compounds, and processes for the preparation thereof
发明人：REDDY DUMBALA SRINIVASA; KOMIRISHETTY KASHINATH; NATARAJAN VASUDEVAN
权利人:COUNCIL SCIENT IND RES
摘要:Solomanamide analogs of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogs, including the synthesis of macrocyclic core of Salomanamide analogs. The Solomanamide analogs of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.

专利号:US-2022364130-A1
优先权日:2017-05-03
标题:Methods and enzyme catalysts for the synthesis of non-canonical amino acids

专利号:CN-110438100-B
优先权日:2019-08-02
标题:A kind of method of biocatalytic synthesis of glycerol glucoside