CAS: 5619-05-6; H-Dl-Val-Ome.Hcl

相似化合物

6306-52-1 7146-15-8 58561-04-9

上下游产品

methanol D,L-valine trans-dichlorobis(2-imino-3-methylbutane acid-methylester)palladium 2(S(CH3)2)(NH2CH(CO°CH3)CH(CH3)2)][PtCl2(S(CH3)2)(NH2CH(CO°CH3)CH(CH3)2)]2-isothi°Cyanato-3-methyl-butyric acid methyl ester (1)DL-2-(2-Benzylthioethylamino)-3-methyl-butanol-(1) (R,S)-methyl 3-methyl-2-{[(2E)-3-phenylprop-2-enoyl]amino}butanoate phenyl>methyl>-DL-valinatemethyl N-3-(diethoxyphosphinyl)methylphenylmethyl-DL-valinate

📜N-苄基-L-缬氨酸甲酯置于2,2,6,6-四甲基哌啶氧化物,Laccasefrom Trametes Versicolor,氧气,溶剂黄146,盐酸体系中,用 水 作为反应溶剂,化学反应 168.0H,以54%的收率获得产物dl-缬氨酸甲酯盐酸盐
参考文献:使用漆酶介导的生物氧化将胺选择性氧化为醛或亚胺
标题:使用漆酶介导的生物氧化将胺选择性氧化为醛或亚胺
摘要:描述了一种在水中苄胺的有效,实用的化学酶促好氧氧化反应,以得到醛或亚胺.选择来自trametes Versicolor的漆酶作为生物催化剂,并以tempo(自由基的2,2,6,6-四甲基哌啶1-氧基)为介质.对水性介质的ph依赖性的研究使我们能够实现对产物选择性的微调.在我们优化的反应条件下,已实现了一系列伯,仲和环状胺的生物氧化.
DOI:10.1002/adsc.201500165

专利信息

专利号:US-9422321-B2
优先权日:2010-09-07
标题 :Pyrimidine nucleoside derivatives, synthesis methods and uses thereof for preparing anti-tumor and anti-virus medicaments
发明人：CHANG JUNBIAO; AN HAOYUN; YU XUEJUN; GUO XIAOHE
权利人:CHANG JUNBIAO; AN HAOYUN; YU XUEJUN; GUO XIAOHE; HIGH & NEW TECH RES CENTER HENAN ACAD OF SCIENCES; ZHENGZHOU GRANLEN PHARMATECH LTD; UNIV ZHENGZHOU
摘要:The present invention relates to the field of pharmacochemistry. Disclosed are fluorinated and azido-substituted pyrimidine nucleoside derivatives, particularly compounds of the formula shown below: n nAlso disclosed are methods of preparation and uses for these compounds. The compounds can be used for preparing medicaments for treating diseases such as tumors and viral infections, and can be used separately or in combination with other medicaments. The compounds also have effective activity against diseases such as tumors and viral infections, while having few side effects, and thus have potential application value.

专利号:US-5939392-A
优先权日:1993-06-03
标 题 :Method of thrombin inhibition
发明人：ANTONSSON KARL THOMAS; BYLUND RUTH ELVY; GUSTAFSSON NILS DAVID; NILSSON NILS OLOV INGEMAR
权利人:ASTRA AB
摘要:The invention relates to new competitive tripeptide inhibitors of trypsin-like serine proteases, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory inhibitors for prophylaxis and treatment of related diseases.

专利号:US-4267344-A
优先权日:1972-09-22
标 题:N-Substituted N-carboxyanhydrides of α-amino acids and their application in the preparation of peptides
发明人：HALSTROM JOHN B; KOVACS KAROLY G
权利人:PROTEINKEMISK INST TILKNYTTET
摘要:N-Substituted N-carboxyanhydrides of α-amino acids, useful in peptide syntheses, and peptide synthesis process using such compounds, are disclosed. The N-substituent is penta(lower alkoxy)benzyl, or optionally substituted 9-xanthyl, 9-thioxanthyl or 9-selenoxanthyl.

专利号:US-10233182-B2
优先权日:2014-04-04
标题 :Substituted spirocyclic inhibitors of autotaxin
发明人：BABISS LEE; CLARK MATTHEW; KEEFE ANTHONY D; MULVIHILL MARK J; NI HAIHONG; RENZETTI LOUIS; RUEBSAM FRANK; WANG CE; XIE ZHIFENG; ZHANG YING
权利人:X RX INC
摘要:The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

专利号:US-5723444-A
优先权日:1993-06-03
标 题:Starting materials in the synthesis of thrombin and kinogenase inhibitors

专利号:US-3948971-A
优先权日:1972-05-03
标题 :N-protected-α-amino acid compounds
发明人：VEBER DANIEL F; BRADY STEPHEN F
权利人:MERCK & CO INC
摘要:Novel N-protected-α-amino acid compounds are disclosed in which the amino functionality is protected by a 1-methylcyclobutyloxycarbonyl or 1-methylcyclohexyloxycarbonyl. Processes for the synthesis of amino acids containing these protecting groups and the use of these novel amino acid compounds in the preparation of peptides are also disclosed.