CAS: 55052-27-2; 6-Chloro-1H-Pyrrolo[2,3-B]Pyridine

该化合物是一种杂交有机化合物,其特点是其结合的丁烯和结构,在6个位置上含有氯替代物,该化合物在环状中具有氮原子特征,有助于其基本性和潜在反应性.该化合物一般在室温下具有固体性,在极地有机溶剂中可能表现出中等溶解性.氯原子的存在可影响其电子特性,使其成为有机合成和药用化学的有用中间体. 6-Chroloo-7-acardole经常因其潜在的生物活动,包括抗微生物和抗癌特性,受到研究,因为其与其它生物活性化合物具有结构相似性.其反应可归因于氮原子的单对,它们可以参与各种化学反应,例如核生殖器替代或与金属离子的协调.与许多化学物质一样,处理应谨慎进行,并遵循适当的安全议定书,以减少使用该物质可能造成的危害.

结构式图片

相似化合物

5912-18-5 1190317-72-6 1332605-39-6

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号849068-50-4 6-氯-吡咯并[2,3-b]吡... | CAS号143468-11-5 (6-CHLORO-1H-PY... | CAS号55052-24-9 7-氮杂吲哚-7-氧化物 | CAS号271-63-6 7-氮杂吲哚 | CAS号272-49-1 4-氮杂吲哚 | CAS号824-51-1 6-甲基-7-氮杂-吲哚 | CAS号1000340-28-2 3-溴-6-甲基-7-氮杂吲哚 | CAS号220896-14-0 6-氯-1h-吡咯并[2,3-... | CAS号896722-50-2 6-氯-1-苯磺酰基-1H-吡... | CAS号896722-51-3 6-甲基-1-(苯基磺酰基)-...

合成工艺路线路线简述

  • 55052-24-9 = 55052-27-2 + 80235-01-4 + 55052-28-3
    反应条件:1.1 Reagents: Methanesulfonyl Chloride Solvents: Dimethylformamide; 1 H,60 - 75 °C; 5 H,70 °C; 70 °C -> 40 °C1.2 Solvents: Water; < 15 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; 0.5 H,10 °C
    标题:Highly Regioselective And Practical Synthesis Of 5-Bromo-4-Chloro-3-Nitro-7-Azaindole
    作者:Han,Chong; Et Al
    参考文献:Organic Process Research & Development 日期:2017 卷标:21(4) 页码:664-668]

    16887-60-8 + 504440-63-5 = 55052-27-2 + 80235-01-4 + 55052-28-3
    反应条件:1.1 Reagents: Tripotassium Phosphate Solvents: Water; Ph 10,10 - 15 °C; 1 H,0 °C2.1 Reagents: Methanesulfonyl Chloride Solvents: Dimethylformamide; 1 H,60 - 75 °C; 5 H,70 °C; 70 °C -> 40 °C2.2 Solvents: Water; < 15 °C2.3 Reagents: Sodium Hydroxide Solvents: Water; 0.5 H,10 °C
    标题:Highly Regioselective And Practical Synthesis Of 5-Bromo-4-Chloro-3-Nitro-7-Azaindole
    作者:Han,Chong; Et Al
    参考文献:Organic Process Research & Development 日期:2017 卷标:21(4) 页码:664-668]

    271-63-6 = 55052-27-2 + 80235-01-4 + 55052-28-3
    反应条件:1.1 Solvents: Ethyl Acetate; < 20 °C; 2 H,25 °C2.1 Reagents: Tripotassium Phosphate Solvents: Water; Ph 10,10 - 15 °C; 1 H,0 °C3.1 Reagents: Methanesulfonyl Chloride Solvents: Dimethylformamide; 1 H,60 - 75 °C; 5 H,70 °C; 70 °C -> 40 °C3.2 Solvents: Water; < 15 °C3.3 Reagents: Sodium Hydroxide Solvents: Water; 0.5 H,10 °C
    标题:Highly Regioselective And Practical Synthesis Of 5-Bromo-4-Chloro-3-Nitro-7-Azaindole
    作者:Han,Chong; Et Al
    参考文献:Organic Process Research & Development 日期:2017 卷标:21(4) 页码:664-668
📜7-氮杂吲哚置于水,间氯过氧苯甲酸,六甲基二硅氮烷,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,乙二醇二甲醚 作为反应溶剂,化学反应 8.0H,反应生成 6-氯-7-氮杂吲哚
参考文献: Aryloxyacetylindoles And Analogs As Antibiotic Tolerance Inhibitors[fr] Aryloxyacétylindoles Et Analogues En Tant Qu'Inhibiteurs De Tolérance Aux Antibiotiques
标题: Aryloxyacetylindoles And Analogs As Antibiotic Tolerance Inhibitors[fr] Aryloxyacétylindoles Et Analogues En Tant Qu'Inhibiteurs De Tolérance Aux Antibiotiques
摘要:该披露提供了芳基氧乙酰基吲哚化合物及类似物的化合物和药物组合物,用于治疗慢性和急性细菌感染.其中某些化合物是一般式(I)(i)的化合物或其药用可接受的盐或前药.该披露的某些化合物是mvfr抑制剂.mvfr抑制剂减少抗生素耐药细菌菌株的形成,对治疗革兰氏阴性细菌感染和减少铜绿假单胞菌的毒力有用.该披露还提供了治疗受试者细菌感染的方法,包括铜绿假单胞菌感染.

海关参考信息

专利信息


专利号:US-8252930-B2
优先权日:2006-07-06
标 题:Azaindole derivatives with a combination of partial nicotinic acetyl-choline receptor agonism and dopamine reuptake inhibition
发明人：STOIT AXEL; COOLEN HEIN K A C; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G
权利人:STOIT AXEL; COOLEN HEIN K A C; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G; SOLVAY PHARM BV
摘要:Azaindole derivatives of formula (I): n nwherein the symbols have the meanings given in the specification, are described. These compounds have a combination of partial nicotinic acetylcholine receptor agonism and dopamine reuptake inhibition. The invention also relates to pharmaceutical compositions containing these compounds, to methods for preparing them, methods for preparing novel intermediates useful for their synthesis, methods for preparing compositions, and uses of such compounds and compositions, for example, their use in administering them to patients to achieve a therapeutic effect in disorders in which nicotinic receptors and/or dopamine transporters are involved, or that can be treated via manipulation of those receptors.

专利号:US-2024360125-A9
优先权日:2021-02-22
标 题 :2-substituted bicyclo[1.1.1]pentanes
发明人：MACMILLAN DAVID W; GARRY OLIVIA L; LIANG YUFAN; HEILMANN MICHAEL
权利人:UNIV PRINCETON
摘要:Provided herein are 2-substituted bicyclo[1.1.1]pentane (BCP) compounds, as well as methods of making the 2-substituted BCP compounds and methods of derivatizing the 2-substituted BCP compounds, particularly at the 2-position. The 2-substituted BCP compounds described herein are useful building blocks in the synthesis of a variety of products, including pharmaceuticals, polymers, liquid crystals, monolayers and supramolecular structures.

专利号:EP-2041131-B1
优先权日:2006-07-06
标 题 :Azaindole derivatives with a combination of partial nicotinic acetylcholine receptor agonism and dopamine reuptake inhibition
发明人：STOIT AXEL; COOLEN HEIN K A C; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G
权利人:ABBOTT HEALTHCARE PRODUCTS BV
摘要:The invention concerns azaindole derivatives having the general formula (I) wherein the symbols have the meanings given in the specification. These compounds have a combination of partial nicotinic acetylcholine receptor agonism and dopamine reuptake inhibition. The invention also relates to pharmaceutical compositions containing these compounds, to methods for preparing them, methods for preparing novel intermediates useful for their synthesis, methods for preparing compositions, and uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in disorders in which nicotinic receptors and/or dopamine transporters are involved, or that can be treated via manipulation of those receptors.

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:de Haro, T.; Garayalde, D.; Nevado, C., Science of Synthesis Knowledge Updates, (2012) 2, 191.
摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 414.
摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 243.
摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 247.
摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 206.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知