CAS: 53054-76-5; 2-(Pyridin-4-yl)Ethane-1-Sulfonic Acid

相似化合物

1851503-92-8 1178052-43-1 68922-18-9

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CAS号100-43-6 4-乙烯基吡啶

4-乙烯基吡啶置于sodium Hydrogensulfite体系中,用 水 作为反应溶剂,以90%的收率获得产物4-吡啶乙磺酸
参考文献: Compounds And Compositions For Treating Conditions Associated With Apj Receptor Activity[fr] Composés Et Compositions Destinés Au Traitement D'états Pathologiques Associés à Une Activité Du Récepteur De L'Apj
标题: Compounds And Compositions For Treating Conditions Associated With Apj Receptor Activity[fr] Composés Et Compositions Destinés Au Traitement D'états Pathologiques Associés à Une Activité Du Récepteur De L'Apj
摘要:本公开涉及化学实体(例如,化合物或药学上可接受的盐和/或水合物和/或化合物的前药),其调节(例如,激活)apelin受体(在此处也称为apj受体;基因符号"aplnr").本公开还涉及含有相同化学实体的组合物,以及使用和制备相同的其他方法.这些化学实体可用于治疗患有减少apj受体活性(例如,抑制或受损的apj受体信号传导;例如,抑制或受损的apelin-Apj受体信号传导)或内源性apelin下调导致疾病,障碍或病症的主体(例如,人类).此类疾病,障碍或病症的非限定示例包括:(i)心血管疾病;(II)代谢紊乱;(iii)与血管病变相关的疾病,障碍和病症;(iv)器官功能衰竭;(v)与感染(例如,微生物感染)相关的疾病,障碍和病症;以及(vi)与前述任何疾病,障碍或病症或在此处公开的任何疾病,障碍或病症并发或合并的疾病,障碍或病症.此类疾病,障碍或病症的更为具体的非限定示例包括肺动脉高压(例如,Pah);心力衰竭;2型糖尿病;肾功能衰竭;败血症;和全身性高血压.

专利信息

专利号:US-9982072-B2
优先权日:2013-10-30
标 题 :Synthesis of acetal compounds
发明人：LOCCUFIER JOHAN
权利人:AGFA GRAPHICS NV; AGFA NV
摘要:A process for the preparation of optionally asymmetric acetal compounds includes reacting a compound containing a hydroxyl group with a vinylether compound in the presence of a zwitterionic catalyst including at least one basic nitrogen containing structural fragment and at least one sulfonic acid group in its structure, with the proviso that a molar ratio of the basic nitrogen to sulfonic acid is 1:1.

专利号:US-7511113-B2
优先权日:2002-04-26
标题:Oligomeric hydroxy arylether phthalonitiles and synthesis thereof
发明人：KELLER TEDDY M; DOMINGUEZ DAWN D
权利人:US NAVY
摘要:An aromatic ether oligomer or polyaromatic ether comprising the formula:n n O—Ar n ;n nwherein Ar is an independently selected divalent aromatic radical; formed by reacting a dihydroxyaromatic with a dihaloaromatic; and wherein the reaction is performed in the presence of a copper compound and cesium carbonate. The polyaromatic ether is formed when neither the dihydroxyaromatic nor the dihaloaromatic is present in an excess amount. The aromatic ether oligomer is formed by using an excess of either dihydroxyaromatic or dihaloaromatic. A phthalonitrile monomer comprising the formula:n n nformed by reacting a 3- or 4-nitrophthalonitrile with a hydroxy-terminated aromatic ether oligomer. A thermoset formed by curing the phthalonitrile monomer. Processes for forming all the above.

专利号:US-5919987-A
优先权日:1994-03-16
标 题:Preparation of alcohols and/or aldehydes
发明人：KNEUPER HEINZ-JOSEF; ARON MAIK; KORGITZSCH FRANK-MICHAEL; NILLES MICHAEL; HARDER WOLFGANG; ROEPER MICHAEL; PACIELLO ROCCO
权利人:BASF AG
摘要:An industrial preparation of aldehydes and/or alcohols from olefins of more than 3 carbon atoms by a catalytic hydroformylation of the olefin reactant at a pressure of from 50 to 1000 bar and a temperature of from 50 to 180° C. in the presence of an uncomplexed rhodium catalyst homogeneously dissolved in the reaction medium. The catalytic activity of the rhodium is maintained, first by extracting it from the initially discharged reaction mixture by means of an aqueous solution of a nitrogen-containing complexing agent such as sulfonated or carboxylated pyridines, quinolines or the like. In a recycle of the complexed rhodium to be reused in the hydroformylation reaction, the aqueous rhodium-containing extract is fed to a precarbonylation stage where it subjected to a required precarbonylation in the presence of an essentially water-insoluble organic liquid and in the presence of carbon monoxide, synthesis gas or another gas mixture containing carbon monoxide at from 50 to 1000 bar and from 50 to 180° C. The mixture discharged from this precarbonylation stage is then separated into an organic phase containing the main part of the rhodium and an aqueous phase containing the complexing agent. The resulting rhodium-containing organic phase with the regenerated catalyst is then fed into the hydroformylation stage to complete its recycle.

专利号:WO-03055887-A1
优先权日:2001-12-21
标 题:Conjugated porphyrin, chlorin or bacteriochlorin chromophore
发明人：BOYLE ROSS WILLIAM; GREENMAN JOHN
权利人:CATALYST BIOMEDICA LTD; BOYLE ROSS WILLIAM; GREENMAN JOHN
摘要:The invention provides a porphyrin, chlorin or bacteriochlorin chromophore, which chromophore comprises one conjugating meso substituent which comprises a conjugating group Z for covalently conjugating said chromophore to a protein so as to enable delivery of the chromophore to a selected biological target in vitro or in vivo, and one, two or three hydrophilic meso substituents, wherein the hydrophilicity of the chromophore is such that either on carrying out conjugation of said chromophore to said protein by way of incubating said chromophore and said protein for one hour under standard protein conjugation conditions in 10% DMSO/water buffered to pH 9, the percentage of non-covalently bound chromophore out of total protein-bound chromophore is 5% or less; or, where said protein is bovine serum albumin, on carrying out conjugation of said chromophore to said protein by way of incubating said chromophore and said protein for one hour under standard protein conjugation conditions in 10% DMSO/water buffered to pH 9, the percentage of non-covalently bound chromophore out of total protein-bound chromophore is 20% or less. The invention further provides methods for the synthesis of such chromophores, and methods for the use of such chromophores in therapy and in analysis.

专利号:CA-2718534-A1
优先权日:2008-03-26
标题 :Process for the synthesis of ethynylcyclopropane

专利号:US-2011275872-A1
优先权日:2008-03-26
标 题 :Process for the synthesis of ethynylcyclopropane