CAS: 529-05-5; Chamazulene

该化合物是一种生物活性松增衍生物,以其独特的芳香结构而得到承认,具有深蓝色的颜色,主要通过剖腹产解剖获得,这是在甘菊(Chamomemile)和Yarror(Achillia Millefolium)等植物中发现的前体;查马祖琳表现出了显著的抗氟和抗氧化特性,其原因是它有能力进行抗腐蚀自由基和调节发炎途径;其富脂环境的稳定性使其适合于针对皮肤刺激和氧化压力的时态配方;此外,其脂质性质增强了皮肤应用的生物利用率;研究表明,在两用机制支持下,在伤口愈合和皮肤条件下可能带来好处.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号13061-96-6 甲基硼酸 | CAS号68151-26-8 Isodehydr°Costu... | CAS号37936-58-6 Azuleno[4,5-b]f... | CAS号93552-70-6 Oxireno[1,2]azu... | CAS号113807-34-4 artenolide | CAS号2767-14-8 6-Oxo-2.8-dimet... | CAS号101447-99-8 1.4-Dimethyl-7-...

合成工艺路线路线简述

  • 合成目标产物 Chamazulen 主要起始原料 Eremanthin
  • (文献来源)合成步骤主要原料 Eremanthin
📜在 Palladium Diacetate,Sodium Tetrahydroborate,Potassium Phosphate,Cerium(Iii) Chloride,伯吉斯试剂体系中,用 四氢呋喃,甲醇,甲苯 作为反应溶剂,化学反应 50.5H,反应生成 母菊薁
参考文献:蓝调疗法:通往青金石的高度灵活的路线.
标题:蓝调疗法:通往青金石的高度灵活的路线.
摘要:
DOI:10.1002/anie.200501276

海关参考信息

专利信息


专利号:US-6881847-B2
优先权日:2001-02-01
标题:Process for the synthesis and recovery of nitramines
发明人:HIGHSMITH THOMAS K; HANKS JAMI M; VELARDE STEPHEN P; BOTTARO JEFFREY
权利人:ALLIANT TECHSYSTEMS INC
摘要:A method is provided for the synthesis of nitramines and the recovery of the nitramines from a clathrate.

专利号:US-10245617-B2
优先权日:2015-07-09
标 题 :Synthesis of surface-functionalized polyamides
发明人:HABRAKEN GIJSBRECHT JACOBUS MARIA; SPRAFKE JOHANNES KLAUS; DA SILVA MARION
权利人:BASF SE
摘要:The present invention relates to a process for producing a surface-functionalized molding (oF) having a functionalized surface (fO). In this process a surface (O) of a molding (F) is brought into contact with a dienophile-containing solution (dL). The surface (O) comprises a polyamide (P) which comprises furan units. These furan units are able to react with the at least one dienophile present in the dienophile-containing solution (dL) to give the surface-functionalized molding (oF) having the functionalized surface (fO).

专利号:US-4285778-A
优先权日:1979-07-13
标题:Process for the manufacture of halogenated hydrocarbons
发明人:CROSBY JOHN; TERRY BERNARD W H
权利人:ICI LTD
摘要:2,2-Dichloro-5-methyl-1,1,1-trifluorohex-4-ene, an intermediate in the synthesis of pyrethroid insecticides, is obtained by continuous distillation, preferably under sub-atmospheric pressure, of a mixture of 5-methyl-2,2,4-trichloro-1,1,1-trifluorohexane, dimethylformamide and lithium bromide, precipitating the chlorofluorocarbons from the distillate with water and separating the desired product from starting material by a further distillation.

专利号:US-5789624-A
优先权日:1995-05-30
标题:Synthesis of and hydroformylation with fluoro-substituted bidentate phosphine ligands
发明人:UNRUH JERRY D; SEGMULLER BRIGITTE E; CHAPA GABRIEL R; PRYOR KENT E
权利人:HOECHST CELANESE CORP
摘要:Hydroformylation of alkenes to aldehydes in the presence of a rhodium complex catalyst is improved by the addition of a novel bidentate ligand of the formula ##STR1## wherein R 1 , R 2 , R 1 ' and R 2 ' are organic radicals selected from alicyclic, aliphatic and aromatic groups of which at least one is preferably substituted with at least one electronegative moiety and the methylene groups are present at the trans-2,3 positions on the norbomane moiety. The invention also provides a novel method for producing the bidentate ligand and novel intermediate phosphine oxide and phosphinous acid compounds.

专利号:US-3766236-A
优先权日:1970-11-27
标 题 :Synthesis of halothiolformates
发明人:THALER W; MUELLER W
权利人:EXXON RESEARCH ENGINEERING CO
摘要:HALOTHIOLFORMATES ARE PREPARED BY REACTING A SULFENYL HALIDE WITH CARBON MONOXIDE UNDER MODERATE CONDITIONS OF TEMPERATURE AND PRESSURE, THE PRODUCTS BEING USEFUL AS PESTICIDES AND AS INTERMEDIATES FOR THE PREPARATION OF CARBAMATE PESTICIDES; REACTIVITY OF THE SULFENYL HALIDE MAY BE ENHANCED BY HEAT, POLAR SOLVENTS, AND/OR LEWIS ACID CATALYSTS.

专利号:US-9987208-B2
优先权日:2013-04-04
标题 :Elastin synthesis/regeneration promoting agent
发明人:NISHIZAKI TOMOYUKI; TANAKA AKITO
权利人:NISHIZAKI BIOINFORMATION RES INSTITUTE
摘要:8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) has an action to promote synthesis and regeneration of elastin, and is useful as an agent for the prophylaxis or improvement of wrinkles, and an anti-aging drug.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Abdelhameed RM, Abdel-Gawad H, Taha M, Hegazi B. Separation of bioactive chamazulene from chamomile extract using metal-organic framework. J Pharm Biomed Anal. 2017 Nov 30;146:126-134. doi: 10.1016/j.jpba.2017.08.020. Epub 2017 Aug 26. pii: E56. doi: 10.3390/foods5030056.
3: Flemming M, Kraus B, Rascle A, Jürgenliemk G, Fuchs S, Fürst R, Heilmann J. Revisited anti-inflammatory activity of matricine in vitro: Comparison with chamazulene. Fitoterapia. 2015 Oct;106:122-8. doi: 10.1016/j.fitote.2015.08.010. Epub 2015 Aug 21. doi: 10.1080/14786419.2014.931393. Epub 2014 Jul 1. doi: 10.1002/cbdv.201200435. Investigations by Isotope Ratio Mass Spectrometry (IRMS). Planta Med. 1990 Oct;56(5):456-60. German. Polish. Hungarian. Russian. French. Czech. Czech. Czech. Undetermined Language.

合成参考文献


摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
参考文献:10.1007/s11655-012-1027-9
摘要:Asadi-Shahmirzadi A, Mozaffari S, Sanei Y, Baeeri M, Hajiaghaee R, Monsef-Esfahani HR, Abdollahi M. Benefit of Aloe vera and Matricaria recutita mixture in rat irritable bowel syndrome: Combination of antioxidant and spasmolytic effects. Chinese Journal of Integrative Medicine. 2012 Dec 21;():1–9. doi: 10.1007/s11655-012-1027-9.
参考文献:10.1248/cpb.50.904
摘要:Rekka E, Chrysselis M, Siskou I, Kourounakis A. Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity. Chem Pharm Bull (Tokyo). 2002 Jul;50(7):904–7. doi: 10.1248/cpb.50.904.
参考文献:10.1021/np060180b
摘要:Rivero-Cruz B, Rivero-Cruz I, Rodríguez JM, Cerda-García-Rojas CM, Mata R. Qualitative and Quantitative Analysis of the Active Components of the Essential Oil from Brickellia veronicaefolia by Nuclear Magnetic Resonance Spectroscopy. J. Nat. Prod. 2006 Jul 27;69(8):1172–6. doi: 10.1021/np060180b.
参考文献:10.1016/j.chroma.2006.08.035
摘要:Ramadan M, Watzer B. Determination of chamazulene carboxylic acid in serum by high-performance liquid chromatography. Development and validation. J Chromatogr A. 2006 Nov 10;1133(1-2):221–5. doi: 10.1016/j.chroma.2006.08.035.
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