CAS: 40230-96-4; ((3-Fluorophenyl)Ethynyl)Trimethylsilane

上下游产品

trimethylsilylacetylene chloro-trimethyl-silane 1-ethynyl-3-fluoro-benzene (trifluoromethyl)trimethylsilane 1-ethynyl-3-fluoro-benzene ethyl 8-(3-fluorophenyl)-6H-thieno[3,2-e]indole-2-carboxylate ethyl 8-(3-fluorophenyl)-7-(trimethylsilyl)-6H-thieno[3,2-e]indole-2-carboxylate 1-fluoro-3-(iodoethynyl)benzene

📜三甲基氯硅烷,1-乙炔基-3-氟苯置于正丁基锂体系中,用 四氢呋喃,正己烷,环己烷 作为反应溶剂,以90%的收率获得产物1-[(三甲基硅基)乙炔基]-3-氟苯
参考文献:Design And Application Of A Low-Temperature Continuous Flow Chemistry Platform
标题:Design And Application Of A Low-Temperature Continuous Flow Chemistry Platform
摘要:A Flow Reactor Platform Technology Applicable To A Broad Range Of Low Temperature Chemistry Is Reported. The Newly Developed System Captures The Essence Of Running Low Temperature Reactions In Batch And Represents This As A Series Of Five Flow Coils,Each With Independently Variable Volume. The System Was Initially Applied To The Functionalization Of Alkynes,Grignard Addition Reactions,Heterocycle Functionalization,And Heteroatom Acetylation. This New Platform Has Then Been Used In The Preparation Of A 20-Compound Library Of Polysubstituted,Fluorine-Containing Aromatic Substrates From A Sequential Metalation-Quench Procedure And Can Be Readily Adapted To Provide Gaseous Electrophile Inputs Such As Carbon Dioxide Using A Tube-In-Tube Reactor.
DOI:10.1021/op500213J