CAS: 35450-37-4; Methyl 3-Bromo-4-Methoxybenzoate

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CAS号121-98-2 茴香酸甲酯 | CAS号99-58-1 3-溴-4-甲氧基苯甲酸 | CAS号74-88-4 碘甲烷 | CAS号14348-41-5 3-溴-4-羟基苯甲酸 | CAS号29415-97-2 3-溴-4-羟基苯甲酸甲酯 | CAS号67-56-1 甲醇 | CAS号105-13-5 对甲氧基苄醇 | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号34841-06-0 3-溴-4-甲氧基苯甲醛 | CAS号99-76-3 尼泊金甲酯 | CAS号34841-06-0 3-溴-4-甲氧基苯甲醛 | CAS号38493-59-3 3-溴-4-甲氧基苄醇 | CAS号99-58-1 3-溴-4-甲氧基苯甲酸 | CAS号181136-33-4 3-溴-4-甲氧基苯并肼 | CAS号269410-10-8 2-甲氧基-5-甲氧羰基苯硼酸频那醇酯 | CAS号7465-86-3 Benzamide,N,N-d... | CAS号81324-61-0 3-溴-4-甲氧基苯甲酰氯 | CAS号89978-72-3 4-(bromomethyl)... | CAS号5566-15-4 Benzoic acid, 4...

4-甲氧基苯甲酸甲酯置于phenyl-L3-Iodanediyl Bis(4-(Trifluoromethyl)Benzoate),三甲基溴硅烷体系中,用 二氯甲烷 用作溶剂,以67%的收率获得3-溴-4-甲氧基苯甲酸甲酯
参考文献:高价碘试剂溴化芳烃的逐步机理.
标题:高价碘试剂溴化芳烃的逐步机理.
摘要:使用双(三氟乙酰氧基)碘苯苄酯和三甲基甲硅烷基溴化物的组合,开发了一种温和,无金属的芳烃溴化方法.提出了原位形成的二溴(苯基)-λ3-碘(phibr2)作为反应中间体.使用pifa / Tmsbr的这种方法已成功应用于大量基材(25个实例).单取代的活化芳烃的处理产生对溴化产物(2U-Z),产率高达83-96%.密度泛函理论计算表明了一种逐步机理,该机理涉及添加双溴,然后进行ii型正离子反应,并伴随六元环的重新芳构化.
Doi:10.1021/acs.Joc.9B02784

专利信息

专利号:WO-2011158257-A1
优先权日:2010-06-18
标题 :Preparation process of fesoterodine and intermediates
发明人：JAIN RAJESH; RAO SIRIPRAGADA MAHENDER; RAO JAGADEESHWAR R; MADADA CHANDRA RAO
权利人:PANACEA BIOTEC LTD; JAIN RAJESH; RAO SIRIPRAGADA MAHENDER; RAO JAGADEESHWAR R; MADADA CHANDRA RAO
摘要:The present invention relates to a process of synthesis of 3,3 dipheylpropylamines, which may be used as pharmaceutical intermediates in the preparation of their pharmacologically active derivatives such as fesoterodine, tolterodine, their enantiomers, pharmaceutically acceptable salts and related compounds useful as antimuscarinic agents.

专利号:WO-2011110556-A1
优先权日:2010-03-09
标 题:Short synthesis of tolterodine, intermediates and metabolites

专利号:US-2013197082-A1
优先权日:2010-03-09
标题:Short synthesis of tolterodine, intermediates and metabolites