CAS: 3339-73-9; 3-(1,3-Dioxoisoindolin-2-yl)Propanoic Acid

该化合物是一种多用途有机化合物,其特征是存在一种与丙胺酸碱性相联系的硫酰胺组,这种结构具有独特的再活性,使其作为制药和农用化学合成的中间体具有价值,其应用包括作为生物活性分子的前体,特别是在研制与伽马--巴有关的化合物时.该化合物在标准条件下表现出稳定,并表明与各种有机反应的兼容性,促进了功能性组变.其晶体形式确保了一致性,这对可再生合成结果至关重要.3-phthalimimoprocial酸的平衡性与亲脂性进一步提高了其在精细化学制造中的效用.

结构式图片

物理性质

MSDS等安全信息

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上下游产品

CAS号85-44-9 苯酐 | CAS号107-95-9 β-丙氨酸 | CAS号883-44-3 N-(3-羟丙基)酞亚胺 | CAS号5460-29-7 N-(3-溴丙基)邻苯二甲酰亚胺 | CAS号22509-74-6 N-乙氧羰基邻苯二甲酰亚胺 | CAS号88-99-3 邻苯二甲酸 | CAS号110-54-3 正己烷 | CAS号505-47-5 3,3'-亚氨基二丙酸 | CAS号2436-29-5 3-邻苯二甲酰亚胺丙醛 | CAS号51132-00-4 2-(4-溴-3-氧代丁基)-... | CAS号5022-29-7 N-乙基邻苯二甲酰亚胺 | CAS号41764-17-4 3,4-二氢-2H-苯并[C]... | CAS号30007-57-9 2H-Isoindole-2-... | CAS号83747-30-2 3-(1-氧代异吲哚啉-2-基)丙酸 | CAS号17137-11-0 3-(1,3-二羰基-1,3-... | CAS号7504-49-6 [4-(1,3-dioxois... | CAS号77361-32-1 N-1-B°C-2-(1',3... | CAS号847924-98-5 3-amino-5-pheny...

合成工艺路线路线简述

    Methyl 3-(1,3-Dioxoisoindolin-2-yl)Propanoate置于硫酸体系中,用80%的收率获得3-(N-苯二甲酰亚氨基)丙酸
    参考文献:Komarova,L. I.; Pokrovskaya-Dukhnenko,E. M.; Zaiko,I. A.,Journal Of Organic Chemistry Ussr (English Translation),1986,Vol. 22,# 11,P. 2089-2092
    标题:Komarova,L. I.; Pokrovskaya-Dukhnenko,E. M.; Zaiko,I. A.,Journal Of Organic Chemistry Ussr (English Translation),1986,Vol. 22,# 11,P. 2089-2092

    海关参考信息

    专利信息


    专利号:US-7060818-B2
    优先权日:2003-02-21
    标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
    发明人：HORWITZ COLIN P; GHOSH ANINDYA
    权利人:UNIV CARNEGIE MELLON
    摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

    专利号:US-2011263540-A1
    优先权日:2008-07-25
    标题 :Small-molecule inhibitors of protein synthesis inactivating toxins
    发明人：PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
    权利人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
    摘要:Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are methods of identifying small-molecule inhibitors of a protein synthesis inhibiting toxin.

    专利号:US-2004167329-A1
    优先权日:2003-02-21
    标 题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process

    专利号:WO-2004076425-A1
    优先权日:2003-02-21
    标题:Improved synthesis of macrocyclic tetraamido compounds and new metal insertion process

    专利号:CN-109851658-B
    优先权日:2019-01-16
    标 题 :A method for one-step synthesis of L-carnosine and truncated L-carnosine synthase

    专利号:CN-113481252-A
    优先权日:2021-08-11
    标题:One-step catalytic synthesis of L-carnosine

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    主要参考文献

    参考标题:Synthesis Of S-Thioacyl Dithiophosphates, Efficient And Chemoselective Thioacylating Agentsproofs For The Reversibility Of Isomerisation Of Anhydrides 1 To 2, Melting Points Of Amides And Thioamides Obtained From Anhydrides 5-7 And 1H, 13C Nmr And Ir Data Of Isolated Anhydrides 5-7, 17 Are Available As Supplementary Data. For Direct Access, See Http://www.Rsc.Org/suppdata/p1/b2/b201233B/
    作者:Leszek Doszczak,Janusz Rachon |发布日期:2002.5.10
    摘要:Easily Available Acyl Dithiophosphates Are Not Stable And Isomerise Reversibly To O-Thioacyl Monothiophosphates, Especially When Subjected To Heating. Much Slower But Probably Irreversible Isomerisation To S-Thioacyl Monothiophosphates Occurs. Since Equilibrium States Are Established And S-Thioacyl (Mono)Thiophosphates Form Slowly, Reaction Mixtures Contain Generally Both Thioacylating And Acylating Agents, And Consequently Cannot Be Used For Efficient Thioacylation. On The Other Hand, Treatment Of A Mixture Of Isomeric Anhydrides With An Excess Of A Dithiophosphoric Acid Leads To Exclusive Formation Of S-Thioacyl Dithiophosphates. They Appear To Be Excellent Thioacylating Agents: Relatively Stable, Inert Towards Water And Oxygen And Therefore Easy To Handle. Reactions With Nitrogen Or Sulfur Nucleophiles Proceed Very Rapidly Under Ambient Conditions, Yielding Respective Thioacyl Derivatives. Isolation Of The Products Is Very Simple. Due To The Low Reactivity Of S-Thioacyl Dithiophosphates Towards Oxygen Nucleophiles They Can Be Used For Direct Thioacylation Of Multifunctional Nucleophiles With Unprotected Hydroxy Groups. Respective Thioacyl Derivatives Cannot Readily Be Obtained Using Other Methods.

    合成参考文献


    摘要:Bolduc, T. G.; Thomson, B.; Sammis, G. M., Science of Synthesis, (2020) , 390.
    摘要:Sasa, H.; Kita, Y.; Dohi, T., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .
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