CAS: 24974-74-1; (2-Bromophenyl)Methanesulfonyl Chloride

上下游产品

1-Bromo-2-bromomethyl-benzene 2-bromobenzylchloride 1-(2-bromophenyl)-N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)methanesulfonamide

2-溴苄氯置于硫脲,盐酸,N-氯代丁二酰亚胺体系中,用 乙醇,水,乙腈 用作溶剂,化学反应 0.25H,反应生成2-溴苄基磺酰氯
参考文献:铑催化芳烃的meta-C-H功能化
标题:铑催化芳烃的meta-C-H功能化
摘要:铑催化的邻-C-H官能化在文献中是众所周知的.本文描述的是xphos负载的铑催化苄基磺酸和苯基乙酸骨架的间-C H烯化反应,并以对甲氧基取代的氰基苯酚为指导基团.两种支架均观测到完全的单选择性.在此方案中,可以耐受与芳烃连接的各种烯烃和官能团.
Doi:10.1002/anie.201701579

专利信息

专利号:US-9012445-B2
优先权日:2012-01-12
标题 :Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; POSLUSNEY MICHAEL S; TARR JAMES C
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 4-(1H-pyrazol-4-yl)benzyl analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.