CAS: 23399-77-1; 5-Chloro-2-Iodobenzotrifluoride

上下游产品

CAS号320-41-2 4-氯-2-三氟甲基苯腈 | CAS号142994-09-0 4-氯-2-(三氟甲基)苯甲酸

2-氨基-5-氯三氟甲苯置于盐酸,Sodium Nitrite,Potassium Iodide体系中,用 水 用作溶剂,化学反应 0.42H,以84%的收率获得5-氯-2-碘三氟甲苯
参考文献:具有邻甲硅烷基的三氟甲基芳烃的单键断裂
标题:具有邻甲硅烷基的三氟甲基芳烃的单键断裂
摘要:实现了在邻位带有氢甲硅烷基的三氟甲基芳烃的单个c-F键的转变.在亲核试剂的存在下,通过三苯甲基阳离子对氢甲硅烷基的活化可以实现选择性的cf键功能化,例如通过烯丙基化,羧化或氯化反应.所得氟甲硅烷基芳烃的进一步衍生得到各种芳族二氟亚甲基化合物.
Doi:10.1002/anie.201604776

专利信息

专利号:US-12428425-B2
优先权日:2020-05-04
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; PANTELEEV JANE; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof

专利号:CN-111170991-A
优先权日:2014-07-11
标 题:Antiproliferative compounds and methods of synthesis thereof