CAS: 22500-92-1; Hexa-2,4-Dienoic Acid

相似化合物

110-44-1 2396-84-1 17102-64-6

上下游产品

pyridine cis-5-Hydroxyhex-2-en-1-saeureethylester p-toluenesulfonyl chloride t-en-2-ynoic acidhex-4t-en-2-ynoic acidc,4t-dienoic acid isobutylamidehexa-2c,4t-dienoic acid isobutylamide (2Z,4E)-Hexa-2,4-dienoic acid [(S)-((2E,8E,10Z,14E)-(1R,5R,13R,17R)-13-hydroxy-3,11-dimethyl-19-methylene-7-oxo-6,21-dioxa-bicyclo[15.3.1]henicosa-2,8,10,14-tetraen-5-yl)-(4-methoxy-benzyloxy)-methyl]-amide (2Z,4E)-Hexa-2,4-dienoic acid [(S)-((2E,8E,10Z,14E)-(1R,5R,17R)-3,11-dimethyl-19-methylene-7,13-dioxo-6,21-dioxa-bicyclo[15.3.1]henicosa-2,8,10,14-tetraen-5-yl)-(4-methoxy-benzyloxy)-methyl]-amide (2Z,4E)-Hexa-2,4-dienoic acid [(S)-[(2E,8E,10Z,14E)-(1R,5R,13R,17R)-13-(tert-butyl-dimethyl-silanyloxy)-3,11-dimethyl-19-methylene-7-oxo-6,21-dioxa-bicyclo[15.3.1]henicosa-2,8,10,14-tetraen-5-yl]-(4-methoxy-benzyloxy)-methyl]-amide

📜2,4-己二烯酸,1,1-二甲基乙基酯,(E,Z)-置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 0.5H,以54%的收率获得山梨酸
参考文献:通过酰胺化锂共轭物的加成合成不对称的sperapbillins B和d.
标题:通过酰胺化锂共轭物的加成合成不对称的sperapbillins B和d.
摘要:将非手性锂(R)-N-烯丙基-N-α-甲基苄基酰胺的非对映选择性共轭加成到(2E,5E)-庚二烯酸甲酯中,然后进行保护基团处理,然后进行碘代环氨基甲酸酯化,可以得到通往核心片段甲基(3R,脂蛋白b和d的5R,6R)-3,6-二氨基-5-羟基庚酸酯.通过用丙酮处理,很容易实现该核心氨基酸的c-3和c-6伯氨基之间的区分.,6-异亚丙基和c-3-亚胺保护的二胺,随后c-6-氮的区域选择性酰化促进了总产率为10.8%的斯培比林d的总合成,以及首次总产率为5.8%的斯培比林b的不对称合成. .
Doi:10.1039/b404962D

专利信息

专利号:US-6258323-B1
优先权日:1998-11-16
标题:Apparatus and method used in multiple, simultaneous synthesis of general compounds
发明人：HORMANN ROBERT EUGENE; GILBERT DARYL EUGENE; SIOMA EDWARD MICHAEL
权利人:ROHM & HAAS
摘要:The apparatus and method of the present invention provides for conducting simultaneous multiple synthesis of general compounds, which often takes place under varied uneven conditions requiring heating, cooling, agitation, reagent/solvent additions to the reactor contents at each reaction vessel location, supply and maintenance of inert atmosphere and means to facilitate the reflux of the reactor contents. Thus, it becomes necessary to monitor and control the reaction conditions during the simultaneous multiple synthesis of general compounds. The apparatus allows the user to connect various independently controlling and conveying means to each reaction vessel through multiple ports provided on a stopper mounted on each reaction vessel. The apparatus of the present invention permits user to readily access the reaction vessels without interrupting the reactions occurring in the adjacent reaction vessels. The unique geometry and shape of the stopper allows positioning of multiple ports, while still providing the stopper with a compact size. As a result, a large array of reaction vessels can be accommodated in the device of the present invention without significantly increasing the overall size of the apparatus. Some of the general compounds that can be readily synthesized by the apparatus and the method of the present invention include inorganic compounds as well as organic compounds, such as oligomers, polymers, agricultural chemicals, drugs, peptides and oligonucleotides.

专利号:US-5780658-A
优先权日:1995-01-10
标 题 :Process for the synthesis of cationic surfactants comprising esterification with basic character amino acids
发明人：MARTINEZ-PARDO MARTA ROSA INFA; MESTRES AUGUSTIN CONTIJOCH; SERRABASA PILAR ERRA
权利人:MIRET LAB
摘要:The process of the invention is directed to the synthesis of cationic type surfactant compounds consisting of natural basic-character amino acids, and any of their homologs, suitably modified for the purpose of obtaining products having specific applications as antimicrobial (biocidal) agents. The process comprises a first step of esterification of an amino acid, and a second step of the condensation of a fatty acid chloride with an esterified amino acid derivative. Nontoxic reaction media and catalysts are used, and a final product free from impurities is obtained. The cost of the process of the invention is reduced from prior art processes due to the use of cheaper starting materials and simpler equipment.

专利号:US-6262251-B1
优先权日:1995-10-19
标题 :Method for solution phase synthesis of oligonucleotides
发明人：PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING
权利人:PROLIGO LLC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.

专利号:US-2025101045-A1
优先权日:2022-01-18
标题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives
发明人：DAS BHASKAR
权利人:LONG ISLAND UNIV
摘要:The present disclosure is concerned with borylated amidoximes useful in the synthesis of biologically relevant drug-like molecules, including functionalized oxadizole and quinazolinone derivatives. Also disclosed are methods of making borylated amidoximes, methods of making functionalized oxadiazole and quinazolinone compounds using the amidoximes, and functionalized oxadiazole and quinazolinone compounds prepared from borylated amidoximes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:WO-9847910-A1
优先权日:1997-04-21
标题:Method for solution phase synthesis of oligonucleotides
发明人：PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S
权利人:NEXSTAR PHARMACEUTICALS INC; PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:US-3856866-A
优先权日:1971-08-20
标题 :Synthesis of codling moth attactant
发明人：HENRICK C; SIDDALL J
权利人:ZOECON CORP
摘要:Stereospecific synthesis of an attractant for the codling moth by reacting a lithium salt of sorbic acid with 6-lithium hexan-1ether to yield a trans-8-trans-10-dodecadien-7-one-1-ether which is reduced to yield a trans-8-trans-10-dodecadien-7-ol-1-ether which in turn is reduced via a 7-sulfonic acid ester to yield a trans-8-trans-10-dodecadien-1-ether and hydrolyzed to trans-8trans-10-dodecadien-1-ol.