CAS: 21740-23-8; (2R,3S,5R)-5-Chloro-2-(((4-Chlorobenzoyl)Oxy)Methyl)Tetrahydrofuran-3-Yl 4-Chlorobenzoate

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📜Methyl 3,5-Dibenzoyloxy-2-Deoxy-α-D-Erythropentofuranoside置于盐酸,溶剂黄146,乙酰氯体系中,用 1,4-二氧六环,氯仿 用作溶剂,以77%的收率获得1-氯-2-脱氧-3,5-二-O-对氯苯甲酰基-D-核糖
参考文献:Processes For Producing Decitabine
标题:Processes For Producing Decitabine
摘要:提供了生产地西他滨的新工艺流程.

专利信息

专利号:US-9109000-B2
优先权日:2012-11-09
标题:Synthesis of nucleosides
发明人：POZZOLI CLAUDIO GIANLUCA; CANEVARI VALENTINA; BRUSASCA MARCO; MENNA LORENZO; CURTI MATTEO
权利人:FARMABIOS SPA; FARMABIOS SPA
摘要:A process for the preparation of nucleosides, derivatives and analogues thereof by coupling reaction of a protected suitable nitrogeneous purine or pyrimidine base, a derivative or analogue thereof and a protected suitable sugar in the presence of SnCl 4 comprising the removal of SnCl4 by adding DMSO directly into the reaction mixture is described. Preferably said process is used for the preparation of antiviral and antitumor agents having a nucleoside or nucleoside-like structure, still more preferably for the preparation of azacytidine, decitabine, chlorfarabine, cladribine, mizoribine. A residual tin content lower than 300 ppm is obtained with said process.

专利号:EP-1112281-B1
优先权日:1998-09-08
标 题:Pteridine nucleotide analogs
发明人：HAWKINS MARY E; PFLEIDERER WOLFGANG; BALIS FRANK
权利人:US GOV HEALTH & HUMAN SERV
摘要:The invention provides pteridine nucleotides of formula (I) which are highly fluorescent and which can be used in the chemical synthesis of fluorescent oligonucleotide. The invention further provides for fluorescent oligonucleotide comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures. The pteridine nucleotides are more stable and possess higher quantum yields than structurally similar pteridine nucleotides.

专利号:US-6716971-B1
优先权日:1998-09-08
标题:Pteridine nucleotide analogs
发明人：HAWKINS MARY E; PFLEIDERER WOLFGANG; BALIS FRANK
权利人:US HEALTH
摘要:The invention provides pteridine nucleotides of formula (I) which are highly fluorescent and which can be used in the chemical synthesis of fluorescent oligonucleotide. The invention further provides for fluorescent oligonucleotide comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures. The pteridine nucleotides are more stable and possess higher quantum yields than structurally similar pteridine nucleotides.

专利号:IT-MI20121918-A1
优先权日:2012-11-09
标题:SYNTHESIS OF NUCLEOSIDES

专利号:US-2014135490-A1
优先权日:2012-11-09
标题:Synthesis of nucleosides

专利号:US-5612468-A
优先权日:1994-05-18
标题:Pteridine nucletide analogs as fluorescent DNA probes
发明人：HAWKINS MARY E; PFLEIDERER WOLFGANG; DAVIS MICHAEL D; BALIS FRANK
权利人:US HEALTH
摘要:The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotides. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.