CAS: 20535-83-5; 2-Amino-6-Methoxypurine

上下游产品

CAS号10310-21-1 2-氨基-6-氯嘌呤 | CAS号124-41-4 甲醇钠 | CAS号83024-94-6 2-amino-9-(2'-d... | CAS号82995-89-9 2-amino-9-[3',5... | CAS号19143-67-0 2-amino-3,7-dim... | CAS号42484-34-4 2-amino-1,9-dim... | CAS号26758-00-9 1,7-Dimethylguanine | CAS号61580-66-3 6-methoxy-9-met... | CAS号7803-88-5 6-O-甲基鸟苷 | CAS号2958-98-7 3-甲基鸟嘌呤 | CAS号879-08-3 9-乙基鸟嘌呤 | CAS号67-56-1 甲醇 | CAS号73-40-5 鸟嘌呤 | CAS号116137-82-7 O(6),7-dimethyl...

2-氨基-6-氯嘌呤置于sodium Hydride体系中,用 二甲基亚砜 用作溶剂,化学反应 25.0H,反应生成2-氨基-6-甲氧基嘌呤
参考文献:Facilitation Of Displacements At The 6-Position Of Purines By The Use Of 1,4-Diazabicyclo[2.2.2]octane As Leaving Group
标题:Facilitation Of Displacements At The 6-Position Of Purines By The Use Of 1,4-Diazabicyclo[2.2.2]octane As Leaving Group
摘要:6-氯嘌呤与1,4-二氮杂双环[2.2.2]辛烷(dabco)的反应生成相应的"dabco-嘌呤"1A-d,这些化合物在二甲基亚砜中与醇盐发生容易的取代反应,生成6-氧取代的嘌呤.
Doi:10.1039/a608207F

专利信息

专利号:WO-2024040628-A1
优先权日:2022-08-24
标 题 :Method for enzyme-catalyzed synthesis of purine nucleoside and composition
发明人：HONG HAO; JAMES GAGE; XIAO YI; ZHANG NA; JIAO XUECHENG; LI MINGJI; LI RUI; ZHANG YANQING; DING SHIMAO; YANG YIMING; LI JUAN
权利人:ASYMCHEM LAB TIANJIN CO LTD
摘要:A method for enzyme-catalyzed synthesis of a purine nucleoside and a composition. The method utilizes a purine nucleoside phosphorylase and any one of the following enzymes: a pyrimidine nucleoside phosphorylase or a thymidine phosphorylase, which catalyze substrates to synthesize the purine nucleoside; the substrates comprise a substrate nucleoside and a substrate base; the pyrimidine nucleoside phosphorylase comprises PyNP, and PyNP is a protein represented by SEQ ID NO: 1; the thymidine phosphorylase comprises TP, and the TP is a protein represented by SEQ ID NO: 2; the purine nucleoside phosphorylase comprises PNP, and the PNP is a protein represented by SEQ ID NO: 3. The present invention can solve the problem of low yield of purine nucleosides synthesized by means of an enzyme method in the prior art, and is suitable for the field of enzyme catalysis.

专利号:US-7541165-B2
优先权日:2001-10-30
标 题 :Molecular detection systems utilizing reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
权利人:RIBOMED BIOTECHNOLOGIES INC
摘要:The present invention provides methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators; using a chain terminator to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase. In one aspect, the invention provides a method for detecting a target protein, DNA or RNA by generating multiple detectable RNA oligoribonucleotides by abortive transcription.

专利号:US-2004054162-A1
优先权日:2001-10-30
标 题:Molecular detection systems utilizing reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
摘要:The present invention provides methods for detecting the presence of a target molecule by the use of nucleotide analogs containing moieties that enable detection. Such analogs may be incorporated into nucleic acids. In one embodiment, nucleotide analogs are used in a process generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators or chain terminators to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase.

专利号:US-5866700-A
优先权日:1993-12-17
标 题:Solid-phase synthesis of oligoribonucleotides
发明人：PFLEIDERER WOLFGANG; SCHNELL RALF; MATYSIAK STEPHAN
权利人:HOECHST AG
摘要:A process for the preparation of oligoribonucleotides of the formula in which n, L, BB, W, T, Y', U, C1 and C2 are as defined in the description, by solid-phase synthesis is described, as are intermediates of the oligoribonucleotides.

专利号:US-9751909-B2
优先权日:2011-09-07
标 题 :Synthesis and uses of nucleic acid compounds with conformationally restricted monomers
发明人：MATRAY TRACY J; MACIAGIEWICZ IWONA M; HOUSTON JR MICHAEL E
权利人:MATRAY TRACY J; MACIAGIEWICZ IWONA M; HOUSTON JR MICHAEL E; MARINA BIOTECH INC
摘要:Processes for synthesis of conformationally restricted nucleomonomers (CRN) by ozonolysis or oxidation of a 2′-vinyl substituted nucleoside precursor with protected 3′-hydroxyl, 4′-hydroxymethyl and 5′-hydroxyl positions. The CRN nucleomonomers can be used to prepare nucleic acid compounds. CRN nucleomonomers for nucleic acid compounds can be prepared in high yields and in multi-gram scale. The nucleic acid compounds can be of various regulatory classes such as antisense RNA for therapeutic modalities useful for treating or preventing diseases or disorders by up- or down-regulating the expression of genes and other nucleic acid based regulatory systems in a cell.

专利号:US-7902196-B2
优先权日:2005-03-17
标 题 :Synthesis of avrainvillamide, strephacidin B, and analogues thereof
发明人：MYERS ANDREW G; HERZON SETH B; WULFF JEREMY EARLE; SIEGRIST ROMAIN; SVENDA JAKUB; ZAJAC MATTHEW ALLEN
权利人:HARVARD COLLEGE
摘要:The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enzyme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores. The compounds of the invention may be used in the treatment of diseases such as cancer, autoimmune diseases, and bacterial infection.