CAS: 19647-70-2; (R)-3-((Acetamidomethyl)Thio)-2-Aminopropanoic Acid

上下游产品

L-Cysteine N-(hydroxymethyl)acetamide l-cysteine hydr°Chloride N-t-butoxycarbonyl-S-acetamidomethyl-L-cysteineN-t-butoxycarbonyl-S-acetamidomethyl-L-cysteine S-[(acetylamino)methyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-cysteine S-(2-hydroxyethylmercapto)-L-cysteine L-cystine

📜L-半胱氨酸盐酸盐无水物,N-羟甲基乙酰胺置于三氟乙酸体系中,化学反应生成S-(乙酰氨基甲基)-L-半胱氨酸
参考文献:使用s-乙酰氨基甲基保护基合成(2-对氟苯基丙氨酸)催产素及其脱氨基类似物.
标题:使用s-乙酰氨基甲基保护基合成(2-对氟苯基丙氨酸)催产素及其脱氨基类似物.
摘要:Abstract[2‐p‐fluorophenylalanine]Oxytocin (1A),Desamino‐[2‐p‐fluorophenylalanine]Oxytocin (1B),And Desamino‐oxytocin (2) Have Been Synthesised Via Intermediates Containing S‐acetamidomethyl‐cysteine. The Protected Linear Peptides Were Built Up Using Both Stepwise And Fragment‐condensation Procedures,And The S‐protecting Groups Were Removed By Iodine With Simultaneous Formation Of The Disulfide Bridge. The Uterotonic Activities In Vitro Of The Analogues Have Been Determined. The Close Similarity Of The 19F‐NMR. Spectra Indicates That The P‐fluorbenzyl Side Chain Is Freely Exposed To The Solvent In The Disulfide‐bridged Hormone Analogues As Well As In Their S‐protected,Acyclic Precursors.
Doi:10.1002/hlca.19740570215

专利信息

专利号:WO-2011060355-A1
优先权日:2009-11-16
标题 :Process for the synthesis of ac-arg-cyclo(cys-d-ala-his-d-phe-arg-trp-cys)-nh2

专利号:JP-2013510881-A
优先权日:2009-11-16
标题 :Method for the synthesis of Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NH2

专利号:EP-0277561-B1
优先权日:1987-02-03
标 题 :New arginine derivative, process for the preparation thereof and its use in peptide synthesis
摘要:N< alpha >-fluorenylmethoxycarbonyl-N-trityl-arginine, a new protected arginine derivative, and its use in peptide syntheses are described. The new compound can be prepared by a three step process, via formation of N< alpha >-trityl-N-trityl-arginine, selective mono-deprotection of said intermediate, and introduction of the fluorenylmethoxycarbonyl group on the amino function.

专利号:US-2018298065-A1
优先权日:2015-09-23
标题 :Protease-resistant streptavidin
发明人：KRIJGSVELD JEROEN; RAFIEE MAHMOUD-REZA
权利人:EUROPEAN MOLECULAR BIOLOGY LABORATORY
摘要:The present invention relates to modified streptavidin molecules that are resistant to cleavage by Lys-C or other proteases. These modified streptavidin molecules can be produced by chemical modification of natural streptavidin, by chemical synthesis or by genetic engineering. The invention also relates to nucleic acid molecules encoding these modified streptavidin molecules, to vectors comprising such nucleic acid molecules, and to cells comprising such nucleic acid molecules or vectors. The invention further relates to solid supports and kits comprising the modified streptavidin molecules. The invention also relates to the use of such modified streptavidin molecules or such solid supports for the capture/immobilization of proteins, peptides, oligonucleotides (e.g. aptamers), polynucleotides (e.g. DNA, RNA, or PNA), lipids, (poly) saccharides, carbohydrates, metabolites, drugs and small molecules, natural and synthetic molecules and to the use of these modified streptavidin molecules or these solid supports in mass spectrometry for the identification of proteins that interact with aforementioned (bio)molecules. The invention further relates to a method for reducing background in mass spectrometry by employing the modified streptavidin molecules.

专利号:CN-103214550-A
优先权日:2013-03-14
标 题:A New Process for Polypeptide Synthesis by Site-directed Cyclization of Multiple Pairs of Disulfide Bonds