专利号:US-6689806-B1 优先权日:1999-03-24 标 题 :Indolinone compounds as kinase inhibitors 发明人:TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS JR G DAVIS; LI XIAOYUAN; LIANG CONGXIN 权利人:SUGEN INC 摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.
专利号:US-9433623-B2 优先权日:2012-09-14 标 题 :Medicinal drug with activity against gram positive bacteria, mycobacteria and fungi 发明人:LEVINA ELIZABETH 权利人:LEVINA ELIZABETH 摘要:The invention relates to chemistry and pharmacology, in particular to synthetic biologically active substances of the pyrimidine series that have antimicrobial activity, and to the method of synthesis thereof. According to the invention there is provided a new substance with activity against gram positive bacteria, mycobacteria and fungi characterized in that it constitutes 5-(2-hydroxybenzylidene) derivatives of the pyrimidinone series with the general formula 1 where XI, X3 are selected from the group containing: H, halogen; N02; X2, X4 are selected from the group containing: H, halogen: Z is selected from the group containing: 0, NNH2, NOH, pei†iydropyrimidine-5-ytidene-2,4,6-trione, perhydropyrimidine-5-ylidene-2,4,6-trione, substituted at the nitrogen atom With alkyl, aryl or aralkyl group; Y is selected from the group containing: H, Na, Li, K.
专利号:RU-2733750-C2 优先权日:2015-09-02 标题:Derivatives of carboxy-substituted (hetero)aromatic rings, method of synthesis and use thereof