CAS: 1499-29-2; Bis(Dichlorophosphoryl)Methane

上下游产品

Tetraisopropyl methylenediphosphonate Methylenediphosphonic acid Tetraethyl methylenediphosphonate methylenediphosphonic acid tetrabutyl esterMethylenediphosphonic acid methylenediphosphonothioic dichloride Tetraisopropyl methylenediphosphonate 2,2'-methylenebis(5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide)

亚甲基二磷酸四异丙酯置于五氯化磷体系中,化学反应生成亚甲基双膦酰二氯
参考文献:关于伯胺使含p-n-p骨架的化合物环化的新发现;二膦酰基甲烷的延伸
标题:关于伯胺使含p-n-p骨架的化合物环化的新发现;二膦酰基甲烷的延伸
摘要:二氯膦(二氯膦酰基)甲胺cl 2 P.nme.p(o)cl 2与3摩尔当量的叔丁基胺反应,得到环二膦氮烷cl [ T ] .与此相反,(bu吨hn)[图形省略]卜吨是从有cl的类似反应中分离的唯一产品2 P.nme.p(S)氯2.Cl 2(o)p.ch 2 .p(o)cl 2与nh 2 Bu T和nh 2 Pr I的相似反应给出了新的一类环化合物,Cl(o)我或卜吨)(1,2,4-氮杂二磷杂环戊烷),但从与cl 2(o)p.ch 2 .ch 2 .p(o)cl 2的类似反应中未发现环状产物.的(me试图环化2 N)氯(o)p-Ch 2-P(o)cl(上nme 2)由nh 2卜吨给出了一个无环产物.(bu吨hn)(me 2 N)(o)p.ch 2 .p(o)(nme 2)(nhbu吨),而不是(me 2 N)(o)[图形省略]卜吨.后者的环状衍生物,是通过加热(me 2 N)2(o)p.ch获得的2
Doi:10.1039/dt9760001113

专利信息

专利号:US-6909010-B2
优先权日:2001-04-11
标题:Facile synthesis of symmetric esters of alkylenebisphosphonic acids
发明人：HERLINGER ALBERT W; STEPINSKI DOMINIQUE C
权利人:UNIV LOYOLA CHICAGO
摘要:A facile synthesis of symmetric esters of C 1 -C 10 alkylenebisphopsphonic acids is disclosed in which a C 1 -C 10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of a catalytic amount of 1H-tetrazole and a base in an aprotic solvent to form a first reaction mixture. The first reaction mixture is maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(chloro ester phosphonate) that is reacted under basic conditions with an excess of a hydroxylated compound to form a second reaction mixture that is itself maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(ester phosphonate) partial ester, homoleptic tetraester or mixed tetraester. The material so formed can be recovered or used as is.

专利号:US-2023295215-A1
优先权日:2020-02-12
标 题 :Novel mrna 5'-end cap analogs modified within phosphate residues, rna molecule incorporating the same, uses thereof and method of synthesizing rna molecule or peptide
发明人：WARMINSKI MARCIN; SIKORSKI PAWEL; KOWALSKA JOANNA; JEMIELITY JACEK
权利人:UNIV WARSZAWSKI; EXPLORNA THERAPEUTICS SP Z O O
摘要:The invention relates to new 5′mRNA end cap analogs, RNA molecules containing them, their uses and methods for their in vitro synthesis, as well as a method for protein or peptide synthesis in vitro or in cell cultures, which method translates the RNA molecule.

专利号:US-2003060648-A1
优先权日:2001-04-11
标题 :Facile synthesis of symmetric esters of alkylenebisphosphonic acids

专利号:US-2005234257-A1
优先权日:2001-04-11
标 题 :Facile synthesis of symmetric esters of alkylenebisphosphonic acids

专利号:WO-02085918-A1
优先权日:2001-04-11
标 题:A facile synthesis of symmetric esters of alkylenebisphosphonic acids

专利号:US-8058031-B2
优先权日:2005-09-29
标 题:Labeled nucleotide analogs and uses therefor
发明人：XU YUE; WEGENER JEFFREY; BIBILLO AREK
权利人:XU YUE; WEGENER JEFFREY; BIBILLO AREK; PACIFIC BIOSCIENCES CALIFORNIA
摘要:Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.