CAS: 14794-31-1; Ethyl 4-Chloro-4-Oxobutanoate

相似化合物

1071-71-2 1490-25-1 27983-42-2

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CAS号1070-34-4 琥珀酸单乙酯 | CAS号108-30-5 丁二酸酐 | CAS号64-17-5 乙醇 | CAS号123-25-1 丁二酸二乙酯 | CAS号2459-05-4 富马酸单乙酯 | CAS号37174-96-2 4-氧代辛酸乙酯 | CAS号41310-80-9 ethyl 4-(4-fluo... | CAS号3153-44-4 3-(4-甲氧基苯甲酰基)丙酸 | CAS号3249-33-0 4-羰基己酸乙酯 | CAS号473693-79-7 ethyl 4-oxo-4-t... | CAS号4653-13-8 4-(1-萘)-4-側氧丁酸 | CAS号1590-22-3 4-(萘-2-基)-4-氧代丁酸 | CAS号14594-24-2 ethyl 5-chloro-... | CAS号14594-25-3 Ethyl 5-bromo-4... | CAS号175394-01-1 ETHYL 4-(3,4-DI...

丁二酸二乙酯置于氢氧化钾,氯化亚砜体系中,用 乙醇 用作溶剂,化学反应 17.5H,反应生成丁二酸单乙酯酰氯
参考文献:C环功能化的prodigiosin类似物的合成和抗癌活性.
标题:C环功能化的prodigiosin类似物的合成和抗癌活性.
摘要:Prodigiosin是天然产物4-甲氧基吡咯基二吡咯甲烯家族的母体成员,并且以其抗癌活性而闻名.合成了一系列新的类似物,在c环上结合了侧基官能酯和β-羰基取代基.β-羰基可轻松分离出isolation二烯,侧酯可进一步衍生.新型的前黄酮通常在来自九种癌细胞类型的60种人类细胞系中保留前黄酮的抗癌活性,既没有共轭的β-羰基(如酮或酯),也没有侧坠酯显着降低其抗癌活性.核心骨架.
Doi:10.1021/jm061088F

专利信息

专利号:US-3959322-A
优先权日:1960-09-22
标 题:Synthesis of 13-alkyl-gon-4-ones
发明人：HUGHES GORDON ALAN; SMITH HERCHEL
权利人:SMITH HERCHEL
摘要:The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.

专利号:US-6608196-B2
优先权日:2001-05-03
标题 :Process for solid supported synthesis of pyruvate-derived compounds
发明人：WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
权利人:GALILEO PHARMACEUTICALS INC
摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

专利号:US-11766432-B2
优先权日:2018-07-27
标题 :Cleavable conjugates of catechol compounds and water-soluble polymers and methods of treatment using the same
发明人：BENTLEY MICHAEL; FANG ZHIHAO; WEIMER REBECCA; VIEGAS TACEY; MOREADITH RANDALL
权利人:SERINA THERAPEUTICS INC
摘要:Described are conjugates comprising a water-soluble polymer linked to a compound comprising a catechol moiety via a cleavable linkage, wherein the cleavable linkage is formed between the water-soluble polymer and a first phenolic hydroxyl group of the catechol moiety and a second phenolic hydroxyl group of the catechol moiety is linked to a blocking group wherein the rate of hydrolytic release of the compound comprising the catechol moiety is controlled, at least in part, through structure or design of the blocking group on the second phenolic hydroxyl group of the catechol moiety. Therefore, the rate of hydrolytic release of the compound comprising the catechol moiety can be tuned through structural design of the group on the second phenolic hydroxyl group of the catechol moiety. Compounds used in the synthesis of the described conjugates and methods of using the described conjugate and other compounds in the treatment of dopamine-responsive disorders are also described.

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-2023135188-A1
优先权日:2017-07-06
标题:Fe/cu-mediated ketone synthesis
发明人：KISHI YOSHITO; YAHATA KENZO; KUMAR VEMULA PRAVEEN; VADDELA SUDHEER BABU
权利人:HARVARD COLLEGE
摘要:Provided herein are methods for preparing ketone-containing organic molecules. The methods are based on novel iron/copper-mediated (“Fe/Cu-mediatedâ€?) coupling reactions. The Fe/Cu-mediated coupling reaction can be used in the preparation of complex molecules, such as halichondrins and analogs thereof. In particular, the Fe/Cu-mediated ketolization reactions described herein are useful in the preparation of intermediates en route to halichondrins.