CAS: 146549-21-5; Fmoc-Gly(Allyl)-Oh

相似化合物

170642-28-1 16338-48-0 170899-08-8

上下游产品

CAS号16338-48-0 (S)-(-)-2-氨基-4-戊烯酸 | CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号740769-74-8 (2S)-N-(2-amino... | CAS号198561-07-8 Fm°C-L-炔丙基甘氨酸 | CAS号659726-50-8 tert-butyl (2S)... | CAS号276869-41-1 (S)-2-Fm°C-氨基辛二... | CAS号159751-46-9 (S)-芴甲氧羰基-2-氨基庚... | CAS号159751-47-0 (S)-2-芴甲氧羰基氨基己二... | CAS号477578-53-3 (S)-2-Fm°C-氨基-4...

在 三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应生成Fmoc-L-烯丙基甘氨酸
参考文献:固体支持的制备含(2 S,6 R)-二氨基庚二酸的肽聚糖片段的方法学的发展
标题:固体支持的制备含(2 S,6 R)-二氨基庚二酸的肽聚糖片段的方法学的发展
摘要:在这里,我们描述了一种有效的固体支持方法的开发,该方法用于立体选择性合成两个含有(2 S,6 R)-二氨基庚二酸,(S)-Ala-γ-(R)-Glu-(2 S,6 R)-A 2 Pm-(R)-Ala 1和γ-(R)-Glu-(2 S,6 R)-A 2 Pm 2.该平台由wang树脂组成,该wang树脂由包含烯丙基甘氨酸的氨基酸链锚定.通过乙烯基甘氨酸与烯烃交叉复分解,得到不饱和保护的(2 S,6 R)-A 2下午固定在坚实的支持.通过从树脂上裂解交叉复分解产物,然后沿着去除保护基团的双键还原来获得肽.此外,这种有效的固相方法将产生肽和多肽文库.
Doi:10.1016/j.Tetlet.2016.02.098

专利信息

专利号:EP-3792250-A1
优先权日:2019-09-13
标题:Synthesis of alpha-amanitin and its derivatives
发明人：SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÃœSSMUTH RODERICH
权利人:PURE BIOORGANICS SIA
摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.

专利号:US-2015148524-A1
优先权日:2012-07-06
标题:Amino acid analogues and methods for their synthesis
发明人：WANG ZHEN; ROBINSON ANDREA; SPICCIA NICOLAS DANIEL; JACKSON WILLIAM ROY
权利人:UNIV MONASH
摘要:A method for the synthesis of an amino acid analogue or a salt, solvate, derivative, isomer or tautomer thereof comprising the steps of: (i) subjecting an amino acid containing a metathesisable group to metathesis with a compound containing a complementary metathesisable group of formula (I) or (II): (Formulae (I), (II)) wherein R 1 and R 2 are independently selected from H and substituted or unsubstituted C 1 to C 4 alkyl; each R 3 is either absent or independently selected from a heteroatom, a substituted or unsubstituted C 1 to C 20 alkyl, and a substituted or unsubstituted C 1 to C 20 alkyl group interrupted by one or more heteroatoms; and each X is independently selected from H and an effector molecule; in the presence of a reagent to catalyse the metathesis to form a dicarba bridge between the amino acid containing a metathesisable group and the compound containing a complementary metathesisable group; and (ii) reducing the dicarba bridge to form a saturated dicarba bridge, wherein the reagent used to catalyse step (i) also catalyses step (ii).

专利号:US-9102708-B2
优先权日:2006-02-17
标 题:Methods for the synthesis of dicarba bridges in organic compounds
发明人：ROBINSON ANDREA JANE; JACKSON WILLIAM ROY; PATEL JIM; ELARIDI JOMANA
权利人:ROBINSON ANDREA JANE; JACKSON WILLIAM ROY; PATEL JIM; ELARIDI JOMANA; SYNGENE LTD
摘要:The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.

专利号:US-8759480-B2
优先权日:2006-02-17
标题:Contoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides
发明人：ROBINSON ANDREA; ELARIDI JOMANA
权利人:ROBINSON ANDREA; ELARIDI JOMANA; SYNGENE LTD
摘要:According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.

专利号:US-2007197429-A1
优先权日:2006-02-17
标 题:Conotoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides

专利号:US-7745573-B2
优先权日:2006-02-17
标题:Conotoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides