CAS: 118159-48-1; Methyl 5'-(Hydroxymethyl)-7,7'-Dimethoxy-[4,4'-Bibenzo[d][1,3]Dioxole]-5-Carboxylate

该化合物是一个复杂的有机化合物,具有独特的结构特征,包括多种甲氧基组和双苯[d][1,3]二氧基框架.该化合物通常具有一系列化学特性,包括有机溶剂中的溶解性,这是含有甲基氧代谢化合物的化合物常见的化合物.其氢氧甲基化合物组可能有助于其再活动,有可能进一步发挥功能或参与诸如酯化或核循环替代等化学反应.碳本甲酸组的存在表明潜在的酸性,而总体结构可能会带来有趣的生物活动,从而成为医药化学或材料科学研究的候选物.此外,该化合物的稳定性和再活性可能受到诸如pH和温度等环境因素的影响.

结构式图片

物理性质

MSDS等安全信息

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上下游产品

联苯双酯 Ddb 73536-69-3
7,7'-Dimethoxy-5'-(Methoxycarbonyl)-4,4'-Bibenzo[d][1,3]Dioxole-5-Carboxylic Acid 211996-66-6
4-[5-(Hydroxymethyl)-7-Methoxy-1,3-Benzodioxol-4-Yl]-7-Methoxy-1,3-Benzodioxole-5-Carboxylic Acid 854750-47-3
7,7-二甲氧基-[4,4]Bi[苯并[1,3]二氧代]-5,5-二羧酸 4,4'-Dimethoxy-5,6,5',6'-Dimethylenedioxy-2,2'-Dibenzoic Acid 105868-34-6

合成工艺路线路线简述

    📜联苯双酯置于4-二甲氨基吡啶,Sodium Tetrahydroborate,乙酸酐,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,Sodium Hydroxide体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 19.0H,反应生成5'-(羟甲基)-7,7'-二甲氧基-[4,4'-二苯并[d][1,3]1,3-二氧杂环戊烯e]-5-甲酸甲酯
    参考文献:联苯双酯-查尔酮杂化物作为一类潜在的p-糖蛋白抑制剂的合成及生物学评估
    标题:联苯双酯-查尔酮杂化物作为一类潜在的p-糖蛋白抑制剂的合成及生物学评估
    摘要:P-糖蛋白(p-Gp)的过表达是成功进行癌症化疗的主要问题之一.为了找到新型有效的p-Gp抑制剂,合成并评估了一系列联苯双酯-查尔酮杂化物.其中,活性最高的化合物8G几乎没有内在的细胞毒性(ic 50 > 200μm),并且通过抑制p-Gp外排功能,比联苯菊酯和维拉帕米(vrp)更有效地增加了罗丹明123在k562 / A02细胞中的蓄积.和8克显示强效的化学增敏效果和持续了长得多的时间(> 24小时)与vrp(<6小时)进行比较.另外,与vrp不同,8G对p-Gp Atpase活性没有刺激,表明它不是p-Gp底物.因此,8G 可能代表开发用于癌症化疗的mdr逆转剂的有希望的领先者.
    Doi:10.1016/j.Bmc.2012.02.050

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    专利信息


    专利号:WO-2025128848-A1
    优先权日:2023-12-12
    标题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
    发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
    权利人:VIGIL NEUROSCIENCE INC
    摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

    专利号:WO-2023081730-A1
    优先权日:2021-11-03
    标 题:4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer
    发明人：ELZEIN ELFATIH; LIU JIWEN
    权利人:TEON THERAPEUTICS INC
    摘要:The present invention relates to 82 specific 4-hydroxy-2-oxo-1,2- dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid CB2 receptor modulators for the treatment of cancer, e.g. to 6-(4- fluorophenyl)-4-hydroxy-1-(2-(4-methylpiperazin-1-yl)ethyl)-2-oxo-N- (spiro[2.3]hexan-5-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxamide (example 1, compound 1) The present description discloses the synthesis and characterisation of the 82 claimed compounds as well as biological assays thereof.

    专利号:CN-119390677-A
    优先权日:2024-12-06
    标题 :Synthesis method of bicyclo-ethanol

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    主要参考文献


    1: Zhen YZ, Li NR, He HW, Zhao SS, Zhang GL, Hao XF, Shao RG. Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats. World J Gastroenterol. 2015 Jun 21;21(23):7155-64. doi: 10.3748/wjg.v21.i23.7155.
    2: Chen X, Zhang J, Han C, Dai H, Kong X, Xu L, Xia Q, Zhang M, Zhang J. A sexual dimorphism influences bicyclol-induced hepatic heat shock factor 1 activation and hepatoprotection. Mol Pharmacol. 2015 Jul;88(1):38-47. doi: 10.1124/mol.114.097584. Epub 2015 Apr 21. doi: 10.1016/j.brainresbull.2013.11.001. Epub 2013 Nov 16.
    5: Yao XM, Li Y, Li HW, Cheng XY, Lin AB, Qu JG. Bicyclol attenuates tetracycline-induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice. Can J Physiol Pharmacol. 2016 Jan;94(1):1-8. doi: 10.1139/cjpp-2015-0074. Epub 2015 Sep 22. doi: 10.1080/10286020.2015.1131678. Epub 2016 Jan 8. doi: 10.1016/j.brainres.2013.06.032. Epub 2013 Jul 10. doi: 10.1007/s40261-013-0136-3. doi: 10.1016/j.ejphar.2016.09.002. Epub 2016 Sep 3. doi: 10.1016/j.ejps.2015.06.020. Epub 2015 Jun 24. doi: 10.5588/ijtld.14.0579. Epub 2012 Jan 28. doi: 10.1631/jzus.B1200263.

    合成参考文献


    摘要:Hu W, Zhang CZ, Li Y. [Resolution of racemic anti-hepatitis drug ( +/- ) -bicyclol]. Yao Xue Xue Bao. 2006 Mar;41(3):221–4.
    摘要:Tang T, Li Y. [Protective effect of bicyclol against acute fatty liver induced by tetracycline in mice]. Yao Xue Xue Bao. 2008 Jan;43(1):23–8.
    参考文献:10.1016/j.ejphar.2008.02.059
    摘要:Zhao J, Chen H, Li Y. Protective effect of bicyclol on acute alcohol-induced liver injury in mice. Eur J Pharmacol. 2008 May 31;586(1-3):322–31. doi: 10.1016/j.ejphar.2008.02.059.
    参考文献:10.1038/aps.2009.194
    摘要:Bao X, Liu G. Bicyclol protects HepG2 cells against D-galactosamine-induced apoptosis through inducing heat shock protein 27 and mitochondria associated pathway. Acta Pharmacologica Sinica. 2010 Feb 05;31(2):219–26. doi: 10.1038/aps.2009.194.
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