CAS: 101930-07-8; (R)-3-Hydroxy-1-Benzylpyrrolidine

上下游产品

N-苄基-3-吡咯烷醇 1-Benzyl-3-Pyrrolidinol 775-15-5
(S)-3-羟基-1-苄基吡咯烷 (S)-N-Benzyl-3-Hydroxypyrrolidine 101385-90-4
(S)-1-(2-Aminobenzyl)Pyrrolidin-3-Ol 1227263-77-5
1-苄基-吡咯烷 N-Benzylpyrrolidine 29897-82-3
(S)-1-苄基-3-甲烷氧基吡咯烷 (S)-1-Benzylpyrrolidin-3-Yl Methanesulfonate 118354-71-5
(2S,3R)-1-Benzyl-2-Vinylpyrrolidin-3-Ol 921202-52-0
(R)-1-Benzyl-3-(Tert-Butyldimethylsilyloxy)Pyrrolidine 1268163-54-7
(3S)-N-苄基-3-羟基吡咯烷-2,5-二酮 (3S)-1-Benzyl-3-Hydroxypyrrolidine-2,5-Dione 101469-91-4 (3R)-1-Benzyl-3-Hydroxypyrrolidine-2,5-Dione 165657-63-6 1-Benzyl-Pyrrolid-3-One 775-16-6

N-苄基-3-吡咯烷醇置于sodium Hydroxide体系中,用 甲醇 用作溶剂,化学反应 3.0H,反应生成(R)-(+)-N-苄基-3-羟基吡咯烷
参考文献:Enzymatic Optical Resolution Ofn-Benzyl-3-Pyrrolidinol
标题:Enzymatic Optical Resolution Ofn-Benzyl-3-Pyrrolidinol
摘要:研究了外消旋 N-苄基-3-吡咯烷醇(2)的酶光学分解.研究发现,只有(R)-2 能被脂肪酶 Amano P 乙酰化,乙酰化率分别为 50%和 100%,即剩余的(S)-醇 2 可以通过化学反应转化为(R)-乙酸酯 3.柱式反应器中的连续反应也可用于这种光学分解.浓缩洗脱溶液后,残留物进行反转反应,得到(R)-乙酸酯 3,收率为 83%,外消旋体的反应效率为 91%e.E..
Doi:10.1271/bbb.59.1287

专利信息

专利号:EP-1926709-A4
优先权日:2005-08-25
标题:PROCESS FOR THE SYNTHESIS OF A 3-HYDROXYPYRROLIDINE CHIRAL COMPOUND AND DERIVATIVES OF SAID HIGH OPTICAL PURITY COMPOUND

专利号:US-5144042-A
优先权日:1990-04-11
标题 :Process for preparing optically active 3-hydroxypyrrolidine derivatives
发明人：SEIDO NOBUO; OKEDA YOSHIKI; KUMOBAYASHI HIDENORI
权利人:TAKASAGO PERFUMERY CO LTD
摘要:A process for preparing optically active 3-hydroxypyrrolidine derivatives useful as intermediates represented by formula (III): ##STR1## wherein Q represents a substituted or unsubstituted phenyl group; and * indicates an asymmetric carbon atom, comprising reacting an optically active 4-halo-3-hydroxybutane derivative represented by formula (I): ##STR2## wherein * is as defined above; R 1 represents a lower alkyl group or a substituted or unsubstituted phenyl group; and X represents a halogen atom, with a benzylamine derivative represented by formula (II): n n H.sub.2 NCH.sub.2 Q (II) n n wherein Q is as defined above, is disclosed. The starting compound (I) is easily available through chemical synthesis. Any complicated procedure or use of an expensive reagent is not required.