CAS: 99-58-1; 3-Bromo-4-Methoxybenzoic Acid

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CAS号100-09-4 对甲氧基苯甲酸 | CAS号35450-37-4 3-溴-4-甲氧基苯甲酸甲酯 | CAS号22002-45-5 3-溴-4-甲氧基甲苯 | CAS号4374-35-0 2-bromo-1-(3-br... | CAS号21702-84-1 2,4-二溴苯甲醚 | CAS号2476-35-9 2-甲氧基-5-溴苯甲酸 | CAS号35310-75-9 1-(3-溴-4-甲氧基苯基)乙烯酮 | CAS号50870-43-4 2-bromo-4-(2-br... | CAS号50870-46-7 trans-3,β-Dibro... | CAS号35450-37-4 3-溴-4-甲氧基苯甲酸甲酯 | CAS号99-50-3 原儿茶酸 | CAS号5197-28-4 2-溴-4-硝基苯甲醚 | CAS号36324-64-8 2-Bromo-4,6-din... | CAS号954815-08-8 3-溴-4-甲氧基-5-硝基-苯甲酸 | CAS号14348-41-5 3-溴-4-羟基苯甲酸 | CAS号21702-84-1 2,4-二溴苯甲醚 | CAS号213598-09-5 3－三氟甲基－4－甲氧基苯甲酸 | CAS号269410-10-8 2-甲氧基-5-甲氧羰基苯硼酸频那醇酯 | CAS号2840-26-8 3-氨基-4-甲氧基苯甲酸

4-甲氧基苯甲腈置于n-溴代丁二酰亚胺(Nbs),水,碘体系中,用 乙腈 作为反应溶剂,化学反应 12.0H,反应生成 3-溴-4-甲氧基苯甲酸
参考文献:N-溴代琥珀酰亚胺碘催化芳基醚芳族溴化反应的机理
标题:N-溴代琥珀酰亚胺碘催化芳基醚芳族溴化反应的机理
摘要:尽管近年来碘催化的反应发展迅速,但是碘催化溴化的例子很少,这些反应的机理尚不清楚.在本文中,我们报道了nbs的i 2催化的芳基醚的芳族溴化反应,并详细介绍了包括动力学研究和动力学同位素效应在内的机理研究.研究表明,该反应实际上是由诱导期形成的ibr催化的,而决定速率的步骤是在ibr辅助下消除wheland中间体的hbr.
DOI:10.1016/j.Tet.2017.10.073

专利信息

专利号:WO-2013117440-A1
优先权日:2012-02-09
标 题 :Synthesis of water-soluble phosphine oxides by pd/c-catalyzed p-c coupling in water
发明人：RANOCCHIARI MARCO; RUMMELT STEPHAN; VAN BOKHOVEN JEROEN A
权利人:SCHERRER INST PAUL
摘要:Cross-coupling between diphenylphosphine oxide and halogenated benzoic acids catalyzed by Pd/C in water is a green, simple and fast protocol to obtain water-soluble tertiary phosphine oxides without the addition of ligands and additives. Low reaction times, microwave irradiation, and high substrate scope make this method general and excellent for lab- and large-scale synthesis without the need to use organic solvents for neither reaction nor workup.

专利号:US-11299484-B2
优先权日:2018-10-10
标 题 :Inhibiting fatty acid synthase (FASN)
发明人：MARTIN MATTHEW W; ZABLOCKI MARY-MARGARET; MENTE SCOT; DINSMORE CHRISTOPHER; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition of FASN, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of FASN, and methods of synthesis of these compounds.

专利号:EP-2626362-A1
优先权日:2012-02-09
标 题:Synthesis of water-soluble phosphine oxides by Pd/C-catalyzed P-C coupling in water