CAS: 957470-58-5; 5-(Difluoromethoxy)-1-((3,4-Dimethoxypyridin-2-yl)Methyl)-2-(((3,4-Dimethoxypyridin-2-yl)Methyl)Thio)-1H-Benzo[d]Imidazole

该化合物是合成用于胃肠治疗的质子泵抑制剂Pantoratole(一种质子泵抑制剂)的关键中间体,该化合物的特征是硫化物联系和氟化氧代金虫,有助于其再活性和制药生产中的实用性.异构体混合物确保下游合成应用的多功能性.其高纯度和稳定性使其适合精确的化学转化,而其定义明确的结构有助于有控制的修改,以便进一步衍生.对于研究人员和制造商旨在开发或优化泛甲子体制剂的研制和制造商来说,这一中间体是必不可少的.

英文名称5-(Difluoromethoxy)-1-((3,4-Dimethoxypyridin-2-yl)Methyl)-2-(((3,4-Dimethoxypyridin-2-yl)Methyl)Thio)-1H-Benzo[d]Imidazole
中文名称N-[(3,4-二甲氧基-2-吡啶基)甲基]泮托拉唑硫醚
IUPAC名称5-(difluoromethoxy)-1-((3,4-dimethoxypyridin-2-yl)methyl)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
其它别名5-(Difluoromethoxy)-1-((3,4-Dimethoxypyridin-2-yl)Methyl)-2- (((3,4-Dimethoxypyridin-2-yl)Methyl)Thio)-1H-Benzo[d]Imidazole 6-(Difluoromethoxy)-1-((3,4-Dimethoxypyridin-2-yl)Methyl)-; 5-(Difluoromethoxy)-1-[(3,4-Dimethoxy-2-Pyridinyl)Methyl]-2-[[(3,4-Dimethoxy-2-Pyridinyl)Methyl]Thio]-1H-Benzimidazole; Pantoprazole Impurity 4; Pantoprazole-16; 5-(Difluoromethoxy)-1-[(3,4-Dimethoxy-2-Pyridinyl)Methyl]-2-{[(3, 4-Dimethoxy-2-Pyridinyl)Methyl]Sulfanyl}-1H-Benzimidazole; 5-(Difluoromethoxy)-1-[(3,4-Dimethoxypyridin-2-yl)Methyl]-2-[(3,4-Dimethoxypyridin-2-yl)Methylsulfanyl]Benzimidazole; Pantoprazole Impurity 13/n-[(3,4-Dimethoxy-2-Pyridinyl)Methyl] Pantoprazole Sulfide/5-(Difluoromethoxy)-1-[(3,4-Dimethoxy-2-Pyridinyl)Methyl]-2-[[(3,4-Dimethoxy-2-Pyridinyl)Methyl]Thio]-1H-Benzimidazole; 1H-Benzimidazole, 5-(Difluoromethoxy)-1-[(3,4-Dimethoxy-2-Pyridinyl)Methyl]-2-[[(3,4-Dimethoxy-2-Pyridinyl)Methyl]Thio]-
CAS编号957470-58-5
MFCD编号:MFCD27977872
FDA UNII编号:Z232L8L5XM
分子式:C24H24F2N4O5S分子量:518.54
产品CID: 2011898

相似结构搜索
InChIKey: SHIGRQLNJGLOLF-UHFFFAOYSA-N
InChI=1S/C24H24F2N4O5S/c1-31-19-7-9-27-16(21(19)33-3)12-30-18-6-5-14(35-23(25)26)11-15(18)29-24(30)36-13-17-22(34-4)20(32-2)8-10-28-17/h5-11,23H,12-13H2,1-4H3
计算化学: 氢键受体数*氢键供体数*可旋转键数*

MSDS等安全信息

合成工艺路线路线简述

72830-09-2 + 2641897-00-7 = 957470-58-5
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 6 H,Rt
标题:Method For Preparing Pantoprazole Impurity Using N,N-Dimethylformamide
参考文献:China]

97963-62-7 + 169905-10-6 = 957470-58-5
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dichloromethane,Water; 15 H,Reflux
标题:Synthesis And Characterization Of Two Impurities In (S)-Pantoprazole As A Chiral Proton Pump Inhibitor
作者:Ke,Jia; Deng,Xin-Shan; Li,Jin-Long; Li,Yong-Peng; Niu,Yuan-Yuan; Et Al
参考文献:Latin American Journal Of Pharmacy 日期:2018 卷标:37(8) 页码:1668-1671

海关参考信息

2905110000-甲醇
2933310010-吡啶
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
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合成参考文献

参考文献:10.1016/j.jpba.2007.05.032
摘要:Reddy GM, Bhaskar BV, Reddy PP, Ashok S, Sudhakar P, Babu JM, Vyas K, Mukkanti K. Structural identification and characterization of potential impurities of pantoprazole sodium. Journal of Pharmaceutical and Biomedical Analysis. 2007 Oct;45(2):201–10. doi: 10.1016/j.jpba.2007.05.032.