CAS: 91476-80-1; 5,6,7,8-Tetrahydroimidazo[1,2-A]Pyrazine

相似化合物

1187830-84-7 345311-03-7 735266-95-2

上下游产品

CAS号274-79-3 吲哚[1,2-A]吡嗪 | CAS号1351991-50-8 7-benzyl-5,6,7,... | CAS号345311-03-7 7-B°C-5,6,7,8-四...

7-Benzyl-5,6,7,8-Tetrahydro-Imidazo[1,2-A]Pyrazine置于palladium 10% On Activated Carbon 甲酸,盐酸体系中,用 甲醇,水 作为反应溶剂,化学反应 7.0H,反应生成 5,6,7,8-四氢咪唑并[1,2-A]吡嗪
参考文献:Inhibitors Of Jnk
标题:Inhibitors Of Jnk
摘要:公式i的化合物或其药用盐,其中:其中m,N,P,Q,X,Y,Z,A,R1,R2,R3,R4,R5和y6如本文所定义.本文披露的化合物和组合物可用于调节jnk的活性并治疗与jnk活性相关的疾病.

专利信息

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-9936723-B2
优先权日:2014-02-12
标题 :Process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones
发明人：FOTSING JOSEPH R
权利人:SENOMYX INC
摘要:The present invention relates to processes and intermediates for the preparation of compounds of formula (I): n nor a salt or oxide thereof, wherein Alk, M1, M2, R1, R2, R3, R4, R5, R6, R7, and n are as described herein. The present invention also relates to compounds of formula (I) and composition comprising a compound of formula (I). Also disclosed is a method of altering or improving the taste of a composition that includes adding to the composition at least one compound of formula (I), in an amount effective to obtain a modified composition having altered or improved taste relative to an otherwise identical composition lacking said compound.

专利号:US-2022118123-A1
优先权日:2019-02-22
标 题 :Combination of ar antagonists and targeted thorium conjugates
发明人：HAMMER STEFANIE; HAGEMANN URS BEAT; HAENDLER BERNARD; LEJEUNE PASCALE; ZITZMANN-KOLBE SABINE; SCHATZ CHRISTOPH; KARLSSON JENNY
权利人:BAYER AG; BAYER AS
摘要:The present invention covers combinations of at least two components, component A and component B, comprising component A being PSMA-TTC, and component B being an antiandrogen selected form AR antagonists such as from cyproterone acetate, bicalutamide, flutamide, nilutamide, enzalutamide, apalutamide, darolutamide or keto-darolutamide, or an AR degrader such as ARV-110, or an ARN-terminal domain binder such as EPI-506, or an antisense oligonucleotide that reduces AR expression such as EZN-4176 or AZD-5312, or an androgen synthesis inhibitor such as abiraterone, particularly abiraterone acetate, seviteronel, galeterone, orteronel or ketoconazole, or a dual AR antagonist and androgen synthesis inhibitor such as ODM-204. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of a hyper-proliferative disease.

专利号:US-10968173-B2
优先权日:2016-07-07
标题:Thiocarbonylthio compounds as chain transfer agents suitable for raft polymerization
发明人：COCHRAN ERIC W; HERNANDEZ NACU; FORRESTER MICHAEL; HOHMANN AUSTIN
权利人:UNIV IOWA STATE RES FOUND INC
摘要:The present invention relates to a compound having the structure of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula (I) and to a process for the synthesis of a polymer using the compound of formula (I) through controlled free radical polymerization.

专利号:US-11149065-B2
优先权日:2017-04-07
标 题:One-bead-two-compound macrocyclic library and methods of preparation and use
发明人：CAI JIANFENG; SHI YAN
权利人:UNIV SOUTH FLORIDA
摘要:A one-bead-two-compound combinatorial synthesis technique provides libraries of macrocyclic peptidomimetic compounds and compositions with use as ligands for the Ephrin type-A receptor 2 (EphA2). The one-bead-two-compound technique and libraries of macrocyclic compounds are useful as research tools in drug discovery and/or to treat or prevent a range of diseases or disorders.

专利号:US-2021403993-A1
优先权日:2020-06-30
标题 :Catalytically controlled sequencing by synthesis to produce scarless dna
发明人：PUGLIESE KAITLIN; PEISAJOVICH SERGIO; MANDELL JEFFREY; MCDONALD SETH
权利人:ILLUMINA INC
摘要:The present disclosure relates to methods comprising (a) contacting a polymerase with a template polynucleotide and a plurality of free nucleotides, wherein the template polynucleotide is hybridized to a complementary polynucleotide comprising a 3′ end overhung by a 5′ terminal fragment of the template polynucleotide, and the plurality of free nucleotides comprise a compound Formula (I); wherein said contacting occurs under a complexation condition, the complexation condition effective to form a complex but not effective to form polymerization, wherein the complex comprises the polymerase, the template polynucleotide, the complementary polynucleotide, and one of the plurality of free nucleotides that is complementary to a first nucleotide of the 5′ terminal fragment of the template polynucleotide; (b) detecting a signal from the fluorescent label; and (c) exposing the complex to a polymerization condition.