CAS: 89797-00-2; Iodixanolrelatedcompoundd(50Mg)(5-[acetyl(2-Hydroxy-3-Methylpropyl)Amino]-N,N-Bis(2,3-Dihydroxypropyl)2,4,6-Triiodo-1,3-Benze-Nedicarboxamide)

上下游产品

1-chloro-3-methoxypropan-2-ol N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide glycidyl methyl ether

📜(甲氧基甲基)环氧乙烷,5-(乙酰氨基)-N,N'-双(2,3-二羟基丙基)-2,4,6-三碘-1,3-苯二甲酰胺置于硼酸,Potassium Hydroxide体系中,用 水 作为反应溶剂,化学反应 72.0H,反应生成 碘喷托
参考文献:A Selective Process For N-Alkylation In Competition With O-Alkylation: Boric Acid,Borax,And Metaborate As A Cheap And Effective Protecting Group Applicable For Industrial-Scale Synthetic Processes
标题:A Selective Process For N-Alkylation In Competition With O-Alkylation: Boric Acid,Borax,And Metaborate As A Cheap And Effective Protecting Group Applicable For Industrial-Scale Synthetic Processes
摘要:This Paper Describes A Selective Process For The N-Alkylation Of Substrates That Contain 1,2-Diol Groups. The Developed Approach Utilises Temporary Protection Of The Diol Groups By Boric Acid,Borax,Or Metaborate. The Introduction Of The Boron-Containing Groups Into The Substrate May Provide,In Addition To Affording The Intended Protection Of The Hydroxyl Groups That May Otherwise Act As Nucleophilic Sites,The Advantages Of Improved Solubility Of The Substrate In Water That Is Used As Solvent. Moreover The N-Alkylation And The Deprotection Of The Diols Are Performed In One Pot,And The Formation Of Undesired O-Alkylated By-Products Is Significantly Reduced. The Paper Gives Examples From The Synthesis Of Several X-Ray Contrast Agents Used In Medical Imaging Diagnostics: Iohexol (Ominipaque,Nycomed Imaging); Iopentol (Imagopaque,Nycomed Imaging); Iodixanol (Visipaque,Nycomed Imaging); Ioversol (Optiray,Mallinckrodt).
DOI:10.1021/op000134X

专利信息

专利号:US-2011021821-A1
优先权日:2009-07-21
标题:Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
发明人：CERVENKA JAN; HUSSAIN KHALID
权利人:GE HEALTHCARE AS
摘要:This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of acetylation of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound Bâ€?) followed by the removal of acetic anhydride.

专利号:US-8962886-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in methanol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with methanol as solvent.

专利号:US-2011021822-A1
优先权日:2009-07-21
标题:continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
发明人：ASKILDSEN ARNE; CERVENKA JAN; HUSSAIN KHALID; SORENSEN THORE JARLE; MALTHE-SORENSSEN DIDRIK
权利人:GE HEALTHCARE AS
摘要:This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of deacetylation of the acetylated hydroxyl group in 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound Bâ€?) followed by crystallisations, filtration, and washing of Compound A.

专利号:US-9688614-B2
优先权日:2013-12-06
标 题:Alternative acetylation process in the synthesis of non-ionic X-ray contrast agents
发明人：SAANUM INGER DAGNY; HAALAND TORFINN; KALLEBERG RITA HESKESTAD
权利人:GE HEALTHCARE AS
摘要:An alternative acetylation process for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents, is described. The process can be performed on an industrial scale to produce Compound A with improved purity and improved yields compared to the established processes.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-12269790-B1
优先权日:2022-04-29
标题:Process for the preparation of 2,4,6-triiodophenol derivatives
发明人：BARANYAI ZSOLT; GUIDOLIN NICOL; LAZZARI FEDERICA; UGGERI FULVIO
权利人:BRACCO IMAGING SPA
摘要:The invention relates to a process for the preparation of a 2,4,6-triiodo-phenol derivative of formula (II), which is useful as an intermediate for the synthesis of conventional X-ray contrast agents, said process comprising the tri-iodination of the correspondent phenol derivative of said 2,4,6-triiodo-phenol derivative by means of an iodinating system comprising I 2 and an oxide or a salt of an element of group 11 of the periodic table.