CAS: 826-81-3; 2-Methyl-8-Quinolinol

相似化合物

14510-06-6 6759-78-0 613-21-8

上下游产品

-butyl vinyl ether 2-amino-phenol LACTIC ACID 2-hydroxynitrobenzene 2-(8-hydroxy-quinolin-2-yl)-indan-1,3-dione 4-(8-acetoxy-2-methyl-[5]quinolylimino)-2,6-dichloro-cyclohexa-2,5-dienone 2‐methyl‐8‐acetoxyquinoline 2-methyl-8-(benzyloxy)quinoline

5,7-二氯-8-羟基喹哪啶置于palladium Hydroxide 10 Wt. % On Activated Carbon,氢气,三乙胺体系中,用 乙醇 作为反应溶剂,43.0 °C,1.5 Mpa 条件下,反应 6.0H,以62.67%的收率获得产物8-羟基喹哪啶
参考文献:利用氯喹那多废渣制备8-羟基-2-甲基喹啉的 方法
标题:利用氯喹那多废渣制备8-羟基-2-甲基喹啉的 方法
摘要:本发明属于有机废渣回收技术领域,具体涉及一种利用氯喹那多废渣制备8‑羟基‑2‑甲基喹啉的方法.该方法在缚酸剂存在下,利用氢化催化剂催化氢化氯喹那多废渣,氯喹那多废渣催化氢化后,过滤,保留固体,酸液溶解,调节溶液ph值,然后萃取,保留有机相,干燥,蒸馏,制得8‑羟基‑2‑甲基喹啉.本发明使用高活性氢化催化剂氢氧化钯碳,避免了钯碳,雷尼镍,铂碳等催化剂对于共轭环上氯代物反应活性的不足,避免了高温与高压等苛刻的反应条件,使反应易于控制,生产周期短,易于工业化.

专利信息

专利号:US-9884067-B2
优先权日:2013-03-14
标 题:Androgen receptor down-regulating agents and uses thereof
发明人：NJAR VINCENT C O; GEDIYA LALJI K; PURUSHOTTAMACHAR PURANIK; GODBOLE ABHIJIT; KWEGYIR AFFUL ANDREW; VASAITIS TADAS
权利人:UNIV OF MARYLAND EASTERN SHORE; UNIV JEFFERSON; UNIV MARYLAND
摘要:The present disclosure provides the design and synthesis of novel steroidal compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant. The compounds are potential agents for the treatment of all forms of prostate cancer and other diseases that depend on functional AR.

专利号:US-10287265-B2
优先权日:2015-03-09
标 题 :Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof
发明人：Puskás László; Kanizsai István; PILLOT THIERRY; GYURIS Márió; Szabó András; Takács Ferenc; Hackler László
权利人:AVIDIN CO LTD; SONEAS RES CO LTD; SYNAGING SAS
摘要:Our invention relates to novel enantiomer derivatives of 8-hydroxyquinoline derivatives with general formula (I) and (II) and the synthesis thereof and pharmaceutically acceptable salts and metal complexes thereof, and the medicinal and/or pharmaceutical compositions comprising these compounds. n n n n n n n n n n The essence of the subject matter of the invention relates to the fact that prior art discloses the biological effect and characteristics only of the racemic products, the novel enantiomer derivatives according to the invention appear in our application for the first. n The subject matter of the invention furthermore relates to a novel, stereoselective synthesis for the preparation of the novel enantiomer derivatives according to the invention. The novel medicinal and/or pharmaceutical compositions comprising these enantiomers are suitable for the treatment of the named diseases, and the enanatiomers are used for manufacture of these compositions. These applications for manufacture of the compositions are also the subject matters of the invention. The compounds according to the invention can be used preferably as cytoprotective, neuroprotective, cardioprotective, anxiolytic and antidepressant agent for treatment of neuropsychiatric and neurologic diseases and diseases in connections with transplantations and with ischemia and reperfusion injuries thereof, and inhibition of organ, advantageously skin graft rejection. According to our studies the R-enantiomer has either sole or high biological effect in some cases.

专利号:EP-2104157-A1
优先权日:2006-12-29
标题 :Solution containing organic el material, method for synthesis of organic el material, compound synthesized by the synthesis method, method for formation of thin film of organic el material, thin film of organic el material, organic el element

专利号:WO-2011077226-A1
优先权日:2009-12-21
标 题 :Procedure for the synthesis of fluorescent probes for metals

专利号:EP-3377507-A1
优先权日:2015-11-17
标 题 :New 5-azido-5-deoxy-2 :3-isopropylidene-d-arabinose compounds; their method of manufacture and their use for the synthesis of ara-n3, kdo-n3 and 4ekdo-n3

专利号:WO-2024233637-A2
优先权日:2023-05-09
标 题:Synthesis of bio-based catecholic acid- and derivatives-functionalized adsorbents for recovery of metals and metalloids from acidic solutions