CAS: 73575-57-2; 2,2',3,4,6'-Pentachlorobiphenyl
该化合物是多氯联苯(PCB)家族的成员,该家族由含有多氯原子的有机化合物组成,与联苯相关联,该化合物的五个氯原子在联苯结构上被取代,这大大改变了其物理和化学特性;该化合物一般在室内温度下是固体,具有较高的热稳定性和抗降解性;2,2',3,4,4,6'-Penta-氯联苯具有水分,这意味着其在水中溶性较低,但可溶解于有机溶剂中.由于其氯化性质,该物质在环境中具有持久性,并可在生物生物中进行生物累积,引起人们对其毒性和潜在健康影响的关切,包括内分泌干扰和致癌性.由于环境和卫生条例,其使用受到很大限制或禁止.
- 英文名称2,2',3,4,6'-Pentachlorobiphenyl
- 中文名称五氯联苯
- IUPAC名称1,2,3-trichloro-4-(2,6-dichlorophenyl)benzene
- 其它别名2,2',3,4,6'-Pentachlorobiphenyl; 2,3,4,2',6'-Pentachlorobiphenyl; PCB 89
- CAS编号73575-57-2
- MFCD编号:MFCD00661144
- FDA UNII编号:4KV4B24A6K
- 分子式:C12H5Cl5分子量:326.43
- 产品CID: 1722992
- 产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: GLOOIONSKMZYQZ-UHFFFAOYSA-N
- 1S/C12H5Cl5/c13-7-2-1-3-8(14)10(7)6-4-5-9(15)12(17)11(6)16/h1-5H
- 计算化学: 氢键受体数*氢键供体数*可旋转键数1.0
MSDS等安全信息
- 危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website. - 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
上下游产品
1,3-dichloro-2-iodobenzene 1,2,3-trichloro-4-iodobenzene合成工艺路线路线简述
海关参考信息
- 2903911000-邻二氯苯
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合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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