CAS: 65262-96-6; 3-Chloro-5-Methoxyphenol

该化合物是一种替代酚化合物,分别由苯酚环3和5位置的氯和甲氧功能组组成,这种结构配置具有独特的回活动性和溶性特性,使其成为有机合成中的宝贵中间体,特别是在制药和农用化学应用中.电排氯组增强了其稳定性,而甲基氧组则促进了其在极地有机溶剂中的溶解性.其明确界定的结构允许在多步骤合成途径中精确地实现功能化.该化合物的特点是高度纯度和一贯性,确保研究和工业过程的可靠性.由于其苯丙基性质,建议适当处理.

结构式图片

欧盟法规

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上下游产品

CAS号7051-16-3 1-氯-3,5-二甲氧基苯 | CAS号929626-16-4 2-(3-氯-5-甲氧基苯基)... | CAS号2845-89-8 3-氯苯甲醚 | CAS号33719-74-3 3,5-二氯苯甲醚 | CAS号124-41-4 甲醇钠 | CAS号10272-06-7 3-氯-5-甲氧基苯胺 | CAS号52780-23-1 5-chlorobenzene... | CAS号7051-16-3 1-氯-3,5-二甲氧基苯 | CAS号90-25-5 1-氯-3,5-二甲氧基-2-硝基苯 | CAS号906008-22-8 3-甲氧基-5-(4,4,5,... | CAS号920035-44-5 3-(3-chloro-5-m... | CAS号920036-16-4 1-chloro-3-meth... | CAS号920036-20-0 3-bromo-5-(3-ch... | CAS号556112-23-3 1-氯-3-乙炔-5-甲氧基苯

合成工艺路线路线简述

    📜1-氯-3,5-二甲氧基苯置于三溴化硼体系中,用 二氯甲烷 作为反应溶剂,化学反应 7.0H,以56%的收率获得产物3-氯-5-甲氧基苯酚
    参考文献:Derivatives Of M-Guaiacol,Their Preparation And Their Uses
    标题:Derivatives Of M-Guaiacol,Their Preparation And Their Uses
    摘要:这项发明涉及对m-石碱酚衍生物的制备及其用途,特别是作为抗菌剂或消毒剂.

    海关参考信息

    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-6828466-B2
    优先权日:2002-07-19
    标题:Process for the synthesis of phenols from arenes
    发明人:MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
    权利人:UNIV MICHIGAN STATE
    摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

    专利号:US-2004030197-A1
    优先权日:2002-07-19
    标 题 :Process for the synthesis of phenols from arenes

    专利号:US-4540834-A
    优先权日:1983-03-02
    标 题:Process for the preparation of metachlorophenols
    发明人:CORDIER GEORGES
    权利人:RHONE POULENC SPEC CHIM
    摘要:The invention relates to a process for the preparation of metachlorophenols. The process consists in selectively hydrodechlorinating, under the action of heat and in the liquid phase, polychlorophenols containing at least one chlorine atom in the meta position relative to the phenolic hydroxyl, by reacting these polychlorophenols with hydriodic acid in a quantity which is sufficient in relation to the chlorine atoms to be removed. The metachlorophenols obtained are organic synthesis intermediates.

    专利号:EP-0055196-A1
    优先权日:1980-12-24
    标题:Process for the synthesis of metachlorophenols

    专利号:EP-0055198-A1
    优先权日:1980-12-24
    标 题:Process for the synthesis of metachlorophenols

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1055/a-1608-5069
    摘要:Xue D, Yang L. Transition-Metal-Catalyzed Hydroxylation Reaction of Aryl Halide for the Synthesis of Phenols. Synlett. 2021 Oct 01;32(19):1891–6. doi: 10.1055/a-1608-5069.
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