CAS: 6094-40-2; Piperazine, Hydrochloride

相似化合物

59813-05-7 58464-47-4 57260-70-5

专利信息

专利号:US-9475814-B2
优先权日:2011-10-03
标题:Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
发明人：HOVEYDA HAMID R; DUTHEUIL GUILLAUME; FRASER GRAEME L; ROY MARIE-ODILE; EL BOUSMAQUI MOHAMED; BATT FREDERIC
权利人:EUROSCREEN SA
摘要:The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.

专利号:US-7943769-B2
优先权日:2006-12-12
标题 :Fluorinated derivative of quinolin-2(1H)-one, method for preparing the same and use thereof as a synthesis intermediate
发明人：LEGROUX DIDIER; MORAGUES VERONIQUE; RUIZ-MONTES JOSE; SALLE LAURENT
权利人:SANOFI AVENTIS
摘要:The invention relates to a fluorinated derivate of quinolin-2(1H)-one (I), to a method for preparing the same, and to the use thereof as an intermediate in the synthesis of 7-fluoro-2-oxo-4-[2-[4-[thieno[3,2-c]pyridine-4-yl)piperazin-1-yl]ethyl]-1,2-dihydro-quinolin-1-acetamide. The invention also relates to the pharmaceutically acceptable salts thereof.

专利号:WO-2006135544-A1
优先权日:2005-06-10
标 题 :SYNTHESIS OF 11-(4[-(2-HYDROXYETHOXY)ETHYL]-PIPERAZINYL)-DIBENZO[b,f][1,4]THIAZEPINE AND ITS FUMARATE SALT
发明人：BUENGER GREG STEVEN; ALEXANDER ANATOLY
权利人:CAMBREX CHARLES CITY INC; BUENGER GREG STEVEN; ALEXANDER ANATOLY
摘要:The invention is directed a method for synthesizing l l-(4-[2-(2- hydroxyethoxy)ethyl]-piperazinyl)-dibenzo[b,f] [l,4]thiazepine (quetiapine) and for recovering quetiapine as its fumarate salt in which dibenzo[b,f][l,4]thiazepine- l l(10H)one is chlorinated in the presence of a trialkyl amine base using a slight molar excess of phosphorous oxychloride to produce l l-chloro-dibenzo[b,f] [l,4]thiazepine which then is alkylated with piperazine to l l-piperazinyldibenzo[b,f] [l,4]thiazepine, which finally is alkylated with 2-(2-chloroethoxy)ethanol.

专利号:WO-2010001407-A2
优先权日:2008-06-05
标 题:Synthesis of 11-(4-[2-(2-hydroxyethoxy)ethyl]- piperazinyl)dibenzo[b,f][1,4]thiazepine and its fumarate salt

专利号:US-5663449-A
优先权日:1989-05-19
标 题 :Intermediate compounds in the synthesis of heteroarylpiperidines, pyrrolidines and piperazines

专利号:US-2008241949-A1
优先权日:2007-03-29
标 题 :Process for preparing quetiapine fumarate
发明人：KANSAL VINOD KUMAR; AHMAD SUHAIL; LAL KANHAIYA; PATIL BHATU TUMBA
权利人:KANSAL VINOD KUMAR; AHMAD SUHAIL; LAL KANHAIYA; PATIL BHATU TUMBA
摘要:Provided is an improved synthesis of quetiapine and pharmaceutically acceptable salts.