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CAS号848841-59-8 5-异丙烯基-吡啶-2-胺 | CAS号1135437-90-9 2-nitro-5-(prop... | CAS号603310-80-1 N-[benzyl]-2-am... | CAS号1072-97-5 2-氨基-5-溴吡啶合成工艺路线路线简述
- 合成目标产物 5-(1-Methylethyl)-2-Pyridinamine 主要起始原料 2-Nitro-5-(Prop-1-En-2-yl)Pyridine
- (文献来源)合成步骤主要原料 2-Nitro-5-(Prop-1-En-2-yl)Pyridine
📜3-溴-4-甲氧基吡啶置于四(三苯基膦)钯,Palladium 10% On Activated Carbon,氢气,Potassium Carbonate体系中,用 1,4-二氧六环,甲醇,水 作为反应溶剂,20.0~100.0 °C,400.01 Kpa 条件下,反应 36.0H,反应生成 5-异丙基吡啶-2-胺
参考文献:Ep3712144
标题:Ep3712144
专利信息
专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人:MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.
专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人:WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.
专利号:WO-2010010150-A1
优先权日:2008-07-25
标题:Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
专利号:US-9856241-B2
优先权日:2013-07-03
标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人:BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.
专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof
专利号:CN-111170991-A
优先权日:2014-07-11
标 题:Antiproliferative compounds and methods of synthesis thereof