其它别名Benzenemethanaminium,N-[4-[[4-(diethylamino)-2-methylphenyl][4-[ethyl[(3-sulfophenyl)methyl]amino]phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfo-,hydroxide, inner salt, sodium salt; Benzenemethanaminium,N-[4-[[4-(diethylamino)-2-methylphenyl][4-[ethyl[(3-sulfophenyl)methyl]amino]phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfo-,inner salt, sodium salt (9CI); C.I. Acid Blue 15 (7CI); C.I. Acid Blue 15,sodium salt (8CI); Acid Blue 15; Acid Blue FF; Acid Coomassie Blue A; AcidLeather Blue RBF; Acid Pure Blue R; Azo Milling Blue B; Brilliant Acid Blue R; Brilliant Milling Blue B; Brilliant Milling Blue BA; Brilliant Milling Blue BW; Brilliant Milling Blue FF; Brilliant Milling BlueSBR; Col°Cid Brilliant Blue FF; Coomassie Brilliant Blue FF; Coomassie Brilliant Blue FFS; Coomassie Brilliant Lake Blue FF; DinacidBrilliant Blue B; Erio Brilliant Blue R; Fenazo Blue XFN; Indacid Blue FF; Lecotan Blue AL; Libacid Coomassie Blue LFF; Milling Blue FF; Monacid CoomarsiBlue FF; Naphthalene Leather Blue FF; Neran Brilliant Blue F; Optanol Blue B; Pacid Coomassi Blue FF; Raviramine Blue BS; Rybacel BlueAR; Serva Blue W; Supranol Blue B; Tertracid MillingBrilliant Blue B; Triacid Blue B; Triacor Royal Blue KRB; Vicoacid Blue 15; Xylene Brilliant Blue BC; Xylene Brilliant Blue FFRX; XyleneMilling Blue BC
专利号:US-2005080260-A1 优先权日:2003-04-22 标 题 :Preparation of prodrugs for selective drug delivery 发明人:MILLS RANDELL L; WU GUO-ZHANG 摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.
专利号:BR-102021009637-A2 优先权日:2021-05-18 标 题:PROCESS OF SYNTHESIS OF ACTIVATED CHARCOAL FROM MACAÚBA FRUIT ENDOCARP, ITS USE AND APPLICATIONS