CAS: 58436-28-5; 5-(4-Hydroxyphenethyl)Benzene-1,3-Diol

该化合物是一种以抗氧化性特性而闻名的,由抗氧化性物质产生的多元酚化合物,其特点是化学结构,包括芳香环上的两个氢氧基组,有助于其生物活动;二氢氟杀螨罗经常研究其潜在的健康惠益,包括防炎,保护心血管和...

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上下游产品

resveratrol (E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol 3,5,4'-trimethoxystilbene 1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethane3,5-di-O-methyldihydroresveratrol α,β-dihydro-3,5-dihydroxy-4'-methoxystilbene 1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethane 4-{4-[2-(3,5-dihydroxyphenyl)ethyl]phenoxy}-5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol

合成工艺路线路线简述

    📜白藜芦醇置于palladium On Activated Charcoal 氢气体系中,用 乙醇 作为反应溶剂,化学反应 2.0H,反应生成 二氢藜芦醇
    参考文献:大黄中的抗氧化剂成分:斯蒂芬类化合物对两种新蒽醌葡萄糖苷的活性和结构的结构要求.
    标题:大黄中的抗氧化剂成分:斯蒂芬类化合物对两种新蒽醌葡萄糖苷的活性和结构的结构要求.
    摘要:发现从5种大黄中提取的甲醇对dpph自由基和.O2-具有清除活性.从大黄(rheum Undulatum L.)的根茎中分离出两个新的蒽醌葡糖苷,以及两个蒽醌葡糖苷,萘葡糖苷和10个对苯二酚.在对大黄成分的自由基清除活性的筛选试验中,丁苯二酚和萘葡萄糖苷具有活性,而蒽醌和番石榴苷则没有活性.此外,大多数对苯二酚通过叔丁基氢过氧化物抑制红细胞膜的脂质过氧化.对各种相关化合物的清除作用的详细研究表明以下结构要求;1)酚羟基对显示活性至关重要;2)没食子酰基部分增强活性;3)葡糖苷部分降低活性;4)二氢二苯乙烯衍生物保持对dpph自由基的清除活性,但它们对.O2-的活性较弱.另外,具有3-羟基和4'-甲氧基的几个对苯二酚抑制黄嘌呤氧化酶.
    DOI:10.1016/s0968-0896(00)00215-7

    海关参考信息

    专利信息


    专利号:US-2024026314-A1
    优先权日:2020-11-25
    标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
    发明人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
    权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
    摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.

    专利号:EP-4251758-A1
    优先权日:2020-11-25
    标 题:Polypeptides for use in the synthesis of bioactive phenolic compounds

    专利号:US-8728453-B2
    优先权日:2011-02-28
    标题 :Combinatorial polymeric compositions for drug delivery
    发明人:DASGUPTA FALGUNI
    权利人:DASGUPTA FALGUNI; INNOVOTECH LLC
    摘要:The present invention is directed towards the synthesis of polymeric drug delivery compositions which would address some of the important and difficult to realize aspects of polymer based drug delivery systems by being, biocompatible, stable, capable of achieving desired drug loading, and safe from accidental release while being non-toxic, easy to fabricate and safe for the environment.

    专利号:WO-2022109736-A1
    优先权日:2020-11-25
    标题:Polypeptides for use in the synthesis of bioactive phenolic compounds

    专利号:CA-3202377-A1
    优先权日:2020-11-25
    标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds

    专利号:US-11898082-B1
    优先权日:2015-09-09
    标题 :Fire resistant phosphate cyanate esters
    发明人:HARVEY BENJAMIN G; CHAFIN ANDREW P; GARRISON MICHAEL D
    权利人:US NAVY
    摘要:This invention describes resins with phosphate cores and a simple, three-step process for their synthesis. Preferred resins are cyanate ester resins with bridging phosphate groups. These resins can be cured to produce thermoset polymers having Tgs of between 131 and >360° C. depending on the number of cyanate ester groups per phosphate and the substitution pattern of the aromatic rings. The high char yields of these resins, up to about 67%, coupled with the phosphate core means that these materials will have applications as fire-resistant polymers. Additionally, these materials can potentially be blended with conventional cyanate esters or other compatible thermosetting resins to improve the fire resistance of composite materials. Other applications may include use in fire-resistant circuit boards, or as surface coatings to reduce flammability of conventional composite materials or thermoplastics.

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    主要参考文献


    1: Oode C, Shimada W, Izutsu Y, Yokota M, Iwadate T, Nihei K. Synthesis of dihydroresveratrol glycosides and evaluation of their activity against melanogenesis in B16F0 melanoma cells. Eur J Med Chem. 2014 Nov 24;87:862-7. doi: 10.1016/j.ejmech.2014.09.092. Epub 2014 Oct 2. doi: 10.1016/j.jchromb.2013.05.002. Epub 2013 May 7. doi: 10.1007/s11357-010-9201-5. Epub 2011 Feb 12.
    4: Oode C, Shimada W, Yokota M, Yamada Y, Nihei KI. Dihydroresveratrol cellobioside and xylobioside as effective melanogenesis activators. Carbohydr Res. 2016 Dec 21;436:45-49. doi: 10.1016/j.carres.2016.11.004. Epub 2016 Nov 9. doi: 10.1021/jf100836j. doi: 10.1002/cbdv.200800229. doi: 10.1002/ptr.5576. Epub 2016 Feb 1. doi: 10.1038/srep22859.
    9: Anisimova NY, Kiselevsky MV, Sosnov AV, Sadovnikov SV, Stankov IN, Gakh AA. Trans-, cis-, and dihydro-resveratrol: a comparative study. Chem Cent J. 2011 Dec 20;5:88. doi: 10.1186/1752-153X-5-88.

    合成参考文献


    参考文献:10.1002/mnfr.201600686
    摘要:Menet M, Baron S, Taghi M, Diestra R, Dargère D, Laprévote O, Nivet‐Antoine V, Beaudeux J, Bédarida T, Cottart C. Distribution of trans‐resveratrol and its metabolites after acute or sustained administration in mouse heart, brain, and liver. Molecular Nutrition Food Res. 2017 Mar 21;61(8). doi: 10.1002/mnfr.201600686.
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