专利号:US-2012282180-A1 优先权日:2011-05-06 标题 :Compounds with Matrix-Metalloproteinase Inhibitory Activity and Imaging Agents Thereof 发明人:KOLB HARTMUTH C; HAUFE GUENTER; BEHRENDS MALTE; KOPKA KLAUS; WAGNER STEFAN; HUGENBERG VERENA; BREYHOLZ HANS-JOERG; HERMANN SVEN; SCHAEFERS MICHAEL 权利人:KOLB HARTMUTH C; HAUFE GUENTER; BEHRENDS MALTE; KOPKA KLAUS; WAGNER STEFAN; HUGENBERG VERENA; BREYHOLZ HANS-JOERG; HERMANN SVEN; SCHAEFERS MICHAEL 摘要:The present invention relates to the field of therapeutic and diagnostic agents and more specifically to compounds of formula (I) that are inhibitors of matrix-metalloproteinases (MMPs) and are useful in the treatment of diseases related thereto such as cardiovascular diseases, inflammatory diseases and malignant diseases. One embodiment of the invention is a compound of formula (I) labeled with a 18-fluorine atom having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the inhibitors of matrix-metalloproteinases (MMPs) of the invention or the corresponding labeled compounds useful as diagnostic imaging agents of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the inhibitors of matrix-metalloproteinases (MMPs) of the invention and of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention.
专利号:US-12221413-B2 优先权日:2015-05-25 标 题:Processes to produce brivaracetam 发明人:WANG PENG; LI PIXU; WEI QIANG; LIU YUANHUA 权利人:SUZHOU PENGXU PHARMATECH CO LTD 摘要:The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.
专利号:EP-2520573-A1 优先权日:2011-05-06 标 题:Compounds with matrix-metalloproteinase inhibitory activity 发明人:HAUFE GUENTER; BEHRENDS MALTE; KOPKA KLAUS; WAGNER STEFAN; HUGENBERG VERENA; BREYHOLZ HANS-JOERG; HERMANN SVEN; SCHAEFERS MICHAEL; KOLB HARTMUTH 权利人:UNIV MUENSTER WILHELMS; SIEMENS MEDICAL SOLUTIONS 摘要:The present invention relates to the field of therapeutic and diagnostic agents and more specifically to compounds of formula (I) that are inhibitors of matrix-metalloproteinases (MMPs) and are useful in the treatment of diseases related thereto such as cardiovascular diseases, inflammatory diseases and malignant diseases. One embodiment of the invention is a compound of formula (I) labeled with a 18-fluorine atom having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the inhibitors of matrix-metalloproteinases (MMPs) of the invention or the corresponding labeled compounds useful as diagnostic imaging agents of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the inhibitors of matrix-metalloproteinases (MMPs) of the invention and of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention.
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