CAS: 56545-22-3; (S)-Methyl 2-Aminobutanoate Hydrochloride

该化合物是一个化学化合物,通常作为研究化学或制药中间体,其特点是分子结构,包括一个矿体,有助于其基本特性;盐状盐的存在表明它是基质质的质子体,提高了其在水中的溶解性,使其适合各种应用,特别是在生物和药用化学方面;该化合物可能显示具体的生物活动,可在药理研究中加以探讨;其稳定性,回活性以及与结构中其他物质的互动取决于其结构中的功能组群;与许多化学物质一样,在处理,储存和处置准则方面,应参考安全数据表,以及与其使用有关的潜在危险;

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85774-09-0 7682-18-0 15399-22-1

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上下游产品

methanol L-2-aminobutyric acid (S)-2-amino-but-3-enoic acid methyl ester hydr°Chloride methyl 2-[(diphenylphosphoryl)amino]butanoateBenzyloxycarbonyl-L-β-amino-β-phenyl-propionyl-L-α-amino-buttersaeuremethylester 3B°C-Tyr-Abu-°CH3 L-methyl 2-aminobutyrate L-(phenylsulfonyl)proline amide L-Abu-NHMe

合成工艺路线路线简述

    📜乙烯基甘氨酸甲酯盐酸盐置于pd-Baso4 氢气体系中,用 甲醇 作为反应溶剂,化学反应 4.0H,反应生成 (2S)-2-氨基丁酸甲酯盐酸盐
    参考文献:L-Vinylglycine
    标题:L-Vinylglycine
    摘要:
    DOI:10.1021/jo01312A002

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    专利信息


    专利号:US-2012282180-A1
    优先权日:2011-05-06
    标题 :Compounds with Matrix-Metalloproteinase Inhibitory Activity and Imaging Agents Thereof
    发明人:KOLB HARTMUTH C; HAUFE GUENTER; BEHRENDS MALTE; KOPKA KLAUS; WAGNER STEFAN; HUGENBERG VERENA; BREYHOLZ HANS-JOERG; HERMANN SVEN; SCHAEFERS MICHAEL
    权利人:KOLB HARTMUTH C; HAUFE GUENTER; BEHRENDS MALTE; KOPKA KLAUS; WAGNER STEFAN; HUGENBERG VERENA; BREYHOLZ HANS-JOERG; HERMANN SVEN; SCHAEFERS MICHAEL
    摘要:The present invention relates to the field of therapeutic and diagnostic agents and more specifically to compounds of formula (I) that are inhibitors of matrix-metalloproteinases (MMPs) and are useful in the treatment of diseases related thereto such as cardiovascular diseases, inflammatory diseases and malignant diseases. One embodiment of the invention is a compound of formula (I) labeled with a 18-fluorine atom having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the inhibitors of matrix-metalloproteinases (MMPs) of the invention or the corresponding labeled compounds useful as diagnostic imaging agents of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the inhibitors of matrix-metalloproteinases (MMPs) of the invention and of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention.

    专利号:US-12221413-B2
    优先权日:2015-05-25
    标 题:Processes to produce brivaracetam
    发明人:WANG PENG; LI PIXU; WEI QIANG; LIU YUANHUA
    权利人:SUZHOU PENGXU PHARMATECH CO LTD
    摘要:The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.

    专利号:EP-2520573-A1
    优先权日:2011-05-06
    标 题:Compounds with matrix-metalloproteinase inhibitory activity
    发明人:HAUFE GUENTER; BEHRENDS MALTE; KOPKA KLAUS; WAGNER STEFAN; HUGENBERG VERENA; BREYHOLZ HANS-JOERG; HERMANN SVEN; SCHAEFERS MICHAEL; KOLB HARTMUTH
    权利人:UNIV MUENSTER WILHELMS; SIEMENS MEDICAL SOLUTIONS
    摘要:The present invention relates to the field of therapeutic and diagnostic agents and more specifically to compounds of formula (I) that are inhibitors of matrix-metalloproteinases (MMPs) and are useful in the treatment of diseases related thereto such as cardiovascular diseases, inflammatory diseases and malignant diseases. One embodiment of the invention is a compound of formula (I) labeled with a 18-fluorine atom having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the inhibitors of matrix-metalloproteinases (MMPs) of the invention or the corresponding labeled compounds useful as diagnostic imaging agents of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the inhibitors of matrix-metalloproteinases (MMPs) of the invention and of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention.

    专利号:JP-2001503782-A
    优先权日:1996-11-22
    标题 :Method and compound for inhibiting release of beta-amyloid peptide and / or its synthesis

    专利号:CN-102558012-B
    优先权日:2012-03-15
    标题:Synthesis method of levetiracetam

    专利号:CN-115557873-A
    优先权日:2022-10-19
    标 题:A kind of synthesis method of buvaracetam methyl esterification impurity

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    主要参考文献

    参考标题:Amino Acid Esters And Amides For Reductive Amination Of Mucochloric Acid: Synthesis Of Novel γ-Lactams, Short Peptides And Antiseizure Agent Levetiracetam (Keppra®)
    作者:Koushik Das Sarma,Ji Zhang,Yun Huang,James G. Davidson |发布日期:2006.8
    摘要:A Simple Methodology Utilizing Mucochloric Acid Anddifferent α- And β-Amino Acid Esters, Amides And Shortpeptides For The Synthesis Of Novel γ-Lactam And γ-Lactam-Based Short Peptides Was Developed. The Synthesis Of An Antiseizure Agent, Levetiracetam (Keppra®) Was Demonstrated. (© Wiley-Vch Verlag Gmbh & Co. Kgaa, 69451 Weinheim, Germany, 2006)

    合成参考文献

    合成方法参考DOI号:10.1002/jlcr.1942
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