CAS: 5341-58-2; 3-Hydroxy-2-Naphthohydrazide

相似化合物

303126-34-3 7732-44-7 58698-35-4

上下游产品

CAS号883-99-8 3-羟基-2-萘甲酸甲酯 | CAS号92-70-6 2-羟基-3-萘甲酸 | CAS号7163-25-9 3-羟基-2-萘甲酸乙酯 | CAS号5417-63-0 2-氨基3-羟基萘 | CAS号304448-55-3 3-羟基-萘-2-羧酸(3,4... | CAS号6962-30-7 2-Naphthaleneca...

2-羟基-3-萘甲酸置于硫酸,一水合肼体系中,用 乙醇 作为反应溶剂,化学反应 2.0H,反应生成 3-羟基-2-萘酸肼
参考文献:基于结构的寄生蛋白酶抑制剂的设计.
标题:基于结构的寄生蛋白酶抑制剂的设计.
摘要:为了简化药物开发的临床前阶段,我们探索了分子目标上的结构数据的实用性以及计算化学和药物化学之间的协同作用.我们专注于寄生虫传染病,特别着重于开发特定的非共价蛋白酶抑制剂,这些抑制剂在寄生虫的生命周期中起着关键作用.通常,没有药物学上感兴趣的酶靶标的结构.在这种情况下,我们通过相关酶与已知结构蛋白的序列相似性对结构进行了建模.例如,我们已经构建了一种基于同源性的模型,其中一种是恶性营养素,滋养体半胱氨酸蛋白酶,并使用计算性配体识别算法dock识别了包括草酸双(2-羟基-1-萘基-亚甲基)酰肼(1)在内的复合酶抑制剂[ring,Cs; 孙e. Jh Mckerow;lee G .;罗森塔尔(rosenthal),Pj,昆茨(kuntz),爱达荷州;科恩,Fe,过程 Natl Acad.科学 Usa 1993,90,3583].通过次黄嘌呤摄取(ic50 7 Microm)判断,化合物1在体外抑制了falcipain(ic50
DOI:10.1016/0968-0896(96)00136-8

专利信息

专利号:US-2022356484-A1
优先权日:2019-09-06
标 题:Genetic modification of plants
发明人：BERMAN JAMES
权利人:BERMAN DR JAMES
摘要:Gene editing complexes are specifically directed to cannabinoid sequences, such as tetrahydrocannabinol (THC), for excision or inactivation of these sequences. The disclosure is directed to the inhibition of synthesis of THC in a cannabis plant. In doing so, THC would never become an active compound within the plant chemistry and chemotype, thereby eliminating the chance of CBD extracts being contaminated with THC.

专利号:CN-115285952-A
优先权日:2022-07-09
标 题:Method for preparing hydrazine sulfate by utilizing waste water generated in synthesis of aromatic hydrazide compounds

专利号:CN-105777578-A
优先权日:2016-04-01
标题:A kind of acylhydrazone cyanide ion sensor molecule and its synthesis and application in detecting cyanide ion in aqueous system

专利号:CN-105777578-B
优先权日:2016-04-01
标 题 :A kind of acylhydrazone cyanide ion sensor molecule and its synthesis and application in detecting cyanide ion in aqueous system

专利号:CN-115477580-A
优先权日:2021-12-10
标 题 :Environment-friendly synthesis method and application of 3-hydroxy-2-methyl naphthoate