CAS: 53135-24-3; Ethyl 2-Methyl-6-Oxo-1,6-Dihydropyrimidine-5-Carboxylate

该化合物是一种火水衍生物,在制药和农用化学合成方面有显著的用途,其结构特征,包括氢氧化物和酯功能组,使其成为建造三环化合物的多种用途中间体.复合物展示出核循环替代和凝聚反应的有利反应性,使其得以用于开发活性药物成分和特殊化学品.在标准条件下的稳定性和精密特性下,它有利于精确的合成应用.研究人员认为这种复合物在生产生物活性分子,特别是在药用化学中,因为那里有突出的基基人.高纯度可以满足严格的工业和学术要求.

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    专利信息


    专利号:US-8188113-B2
    优先权日:2006-09-14
    标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
    发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
    权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
    摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

    专利号:US-6140505-A
    优先权日:1995-03-10
    标 题:Synthesis of benzo fused heterocyclic sulfonyl chlorides

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    合成参考文献


    参考文献:10.1007/s40242-012-2131-2
    摘要:Lu H, Wang S, Li Q, Wang Y. Design, synthesis and evaluation of 6-oxo-1, 6-dihydropyrimidine-2,5-dicarboxamide derivatives as MMP 13 inhibitors. Chemical Research in Chinese Universities. 2012 Dec 12;29(1):67–70. doi: 10.1007/s40242-012-2131-2.
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