CAS: 5176-27-2; Tert-Butyl 1H-Pyrrole-1-Carboxylate

相似化合物

2051-97-0 96-54-8 17639-64-4

二碳酸二叔丁酯置于4-二甲氨基吡啶,吡咯体系中,用 乙腈 作为反应溶剂,化学反应 2.5H,以83%的收率获得产物1-吡咯甲酸叔丁酯
参考文献:环状二芳基 λ3-溴烷:通过环加成反应快速获得分子复杂性
标题:环状二芳基 λ3-溴烷:通过环加成反应快速获得分子复杂性
摘要:联芳基化合物在有机合成中有着广泛的应用.然而,由于制备具有挑战性,顺序多取代的联芳基化合物尚未得到充分开发.在此,我们报道了通过环状二芳基 λ 3-溴的周环反应合成不对称的 2,3,2',3',4-取代的联芳基.官能团耐受性和原子经济性允许在单个反应步骤中获得分子复杂性.连续流动协议已被设计用于放大反应,而后功能化已开发利用剩余的 Br 原子.
DOI:10.1021/acs.Orglett.1C03278

专利信息

专利号:US-5591854-A
优先权日:1994-10-14
标 题 :Enantioselective synthesis of seven-membered carbocycles and tropanes
发明人：DAVIES HUW M L
权利人:UNIV WAKE FOREST
摘要:A process of enantioselective synthesis of seven-membered carbocycles in the presence of di-rhodium(II) tetracarboxylate catalysts.

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2018051042-A1
优先权日:2016-08-22
标题 :Methods for forming saturated (hetero)cyclic borylated hydrocarbons and related compounds
发明人：SMITH III MILTON R; SHANNON TIMOTHY M; MALECZKA JR ROBERT E; FORNWALD RYAN M
权利人:UNIV MICHIGAN STATE
摘要:The disclosure relates to methods for forming at least partially saturated cyclic and heterocyclic borylated hydrocarbons, as well as related compounds, which can be precursor compounds in the synthesis of any of a variety of pharmaceutical or medicinal compounds with a desired structure and/or stereochemistry for drug synthesis or drug candidate evaluation. The methods generally include reduction of an unsaturated cyclic or heterocyclic borylated hydrocarbon having a boron-containing substituent at an sp 2 -carbon, where such reduction converts the sp 2 -carbon to an sp 3 -carbon at the point of attachment of the boron-containing substituent. The methods can exhibit a selectivity for syn-addition during reduction, which can provide stereospecific products, such as when the unsaturated cyclic or heterocyclic reactant is multiply substituted with boron groups and/or other functional groups.

专利号:US-2002010339-A1
优先权日:1998-05-26
标 题:Method for synthesis of halopyridyl-acyclopentane derivative and intermediate thereof

专利号:US-9533957-B2
优先权日:2012-04-06
标题:Tetrazines and method of synthezising the same
发明人：DEVARAJ NEAL K; YANG JUN
权利人:UNIV CALIFORNIA
摘要:Provided herein, inter alia, are compositions and methods of synthesis and detection of tetrazines, e.g., a tetrazine of formula n nand diazonorcaradienes.