CAS: 515-82-2; N-(2,2,2-Trichloro-1-Hydroxyethyl)Formamide

上下游产品

CAS号77287-34-4 甲亚胺酸 | CAS号75-87-6 三氯乙醛 | CAS号3659-66-3 N-Formyl-1,2,2,... | CAS号5816-02-4 10,10'-(1,2-eth...

📜三氯乙醛,Formamide 以 甲苯 作为反应溶剂,化学反应 0.5H,以89%的收率获得产物氯醛甲酰胺
参考文献:Vrabel,Viktor; Pavelcik,Frantisek; Kelloe,Eleonora,Collection Of Czechoslovak Chemical Communications,1985,Vol. 50,# 8,P. 1619-1628
标题:Vrabel,Viktor; Pavelcik,Frantisek; Kelloe,Eleonora,Collection Of Czechoslovak Chemical Communications,1985,Vol. 50,# 8,P. 1619-1628

专利信息

专利号:US-9764047-B2
优先权日:2009-04-17
标题:Method for obtaining novel derivatives of naphthalene for the in vivo diagnosis of alzheimer's disease
发明人：SABLÓN CARRAZANA MARQUIZA; RODRIGUEZ-TANTY CHRYSLAINE; PERERA PINTADO ALEJANDRO; RIVERA MARRERO SUCHITIL; PEREZ PERERA RAFAELA; LÓPEZ BARROSO ROSA MARIA; PRATS CAPOTE ANAIS; VÉLEZ CASTRO HERMÃ?N; PÉREZ MARTÃ?NEZ CARLOS SERAFIN; VALDÉS SOSA PEDRO
权利人:SABLÓN CARRAZANA MARQUIZA; RODRIGUEZ-TANTY CHRYSLAINE; PERERA PINTADO ALEJANDRO; RIVERA MARRERO SUCHITIL; PEREZ PERERA RAFAELA; LÓPEZ BARROSO ROSA MARIA; PRATS CAPOTE ANAIS; VÉLEZ CASTRO HERMÃ?N; PÉREZ MARTÃ?NEZ CARLOS SERAFIN; VALDÉS SOSA PEDRO; CENTRO DE NEUROCIENCIAS DE CUBA
摘要:This invention relates to a chemistry branch, particularly to the field of compounds' organic synthesis that belongs to the aromatic bicyclic or naphthalene category, used in the detection of amyloid sheets. These new naphthalene derivatives have a general formula: Wherein R represents mutually independent groups. In I: R 1 :-alkylenyl-C(O)NH-alkylenyl-R 3 , -alkylenyl-C(O)O—R 4 , R 3 :—COOH, —OH, —SH, —NH 2 , -alkyl-NH-alkyl-N-dithiocarbamate alkaline earth metal salts, R 4 : H, succinimidyl group, R 2 : —H,-alkyl. In II: R 1 : -alkyl, -alkylenyl-halide-alkylenyl-hydroxyl-alkylenyl-O-aryl, —O-alkylsulfonate alkylenyl, R 2 : -halide-alkylenyl-O-aryl, -alkylenyl-O-alkylsulfonate, -alkylenyl-halide-, —CH(O), —HCâ•?C(CN) 2 , —HCâ•?CHNO 2 , -alkylenyl-NH 2 , -alkylenyl-NH-alkyl, -alkylenyl-alkyl-N-dithiocarbamate alkaline salts. The terms “alkylâ€? and “alkylenylâ€? refer to linear or branched aliphatic chains, preferably from 1 to 4 carbon atoms and the term halide to fluorine, bromine or iodine. These compounds are neutral, lipophilic and have low molecular weight and therefore they cross the blood brain barrier and attach to the amyloid sheets. The present invention provides procedures for obtaining naphthalene derivatives with good yields, which can be practical, economical and adapted to a larger-scale manufacturing. We are unaware whether th compounds presented in this invention have been previously reported.

专利号:CN-113402516-B
优先权日:2021-06-04
标题:A method for the synthesis of isoquinolinone derivatives by the room temperature C-H activation/cyclization cascade reaction of N-chloroamides

专利号:CN-113402516-A
优先权日:2021-06-04
标 题 :A method for the synthesis of isoquinolinone derivatives by the room temperature C-H activation/cyclization cascade reaction of N-chloroamides

专利号:CN-114315530-B
优先权日:2021-12-31
标 题 :Preparation technology of m-tert-butylphenol and synthesis method of etoxazole

专利号:EP-0649429-B1
优先权日:1992-06-24
标题 :Heteroatomic oligonucleoside linkages
发明人：COOK PHILLIP DAN; SANGHVI YOGESH SHANTILAL
权利人:ISIS PHARMACEUTICALS INC
摘要:Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligonucleotides with three or four atom linking groups provide unique oligonucleotide-mimicking macromolecules that are useful in regulating RNA expression and in therapeutics. Methods of synthesis and use also are disclosed.

专利号:CN-106977429-B
优先权日:2010-05-11
标 题:Compositions, methods and systems for synthesis and use of contrast agents