CAS: 50-19-1; Oxyfenamate

该化合物是具有抑制环氧基酶酶的能力,在综合涉及炎症和疼痛信号的蛋白质中发挥着关键作用.Oxyfenamate通常被作为白色的脱白晶粉,在有机溶剂中溶解,但在水中溶解度有限.其分子结构具有一个苯基组和一个矿物质功能组,有助于其药性特性.除了其抗炎效应外,还研究氧基苯甲酯在治疗各种条件(包括关节炎)中的潜在应用.然而,与许多非国家行为者一样,它可能与副作用有关,特别是胃肠问题及其使用受到监测.

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    专利信息


    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

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    主要参考文献


    1: Gurney BF. Chemotherapy in dental practice barbiturate substitures. 4. Hydroxyphenamate and oxanamide. Dent Dig. 1970 Feb;76(2):112-3.

    合成参考文献


    摘要:Psychotropic Drugs and Related Compounds, 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972, -(394), 1972
    摘要:Diseases of the Nervous System, Supplement., 22(9), 1961
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