CAS: 4853-75-2; 2-(Ethylsulfonyl)Propane

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CAS号5145-99-3 乙基异丙基硫醚

📜乙基异丙基硫醚置于potassium Tungstate 硫酸,双氧水体系中,化学反应 2.0H,以91%的收率获得产物乙基异丙基砜
参考文献:Ep2441751
标题:Ep2441751

专利信息

专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.

专利号:WO-2023214577-A1
优先权日:2022-05-02
标 题 :Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO; NOMURA KENICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:The present invention addresses the problem of a desired elongation reaction not progressing as a result of a 6-membered cyclic amidine skeleton structure and a diketopiperazine formed when removing an N-terminated protective group during peptide synthesis. The inventors have discovered that it is possible to solve said problem during peptide production by treating a peptide protected by an N-terminated amino group in a protective group having an Fmoc skeleton by using a base which has a pKa of 23 or higher in an acetonitrile of a conjugate acid in a specific solvent, and next, performing peptide chain elongation.

专利号:US-7741487-B2
优先权日:2004-08-26
标题 :Method for producing quaterrylene-3,4:13, 14-tetracarboxy diimides by direct synthesis
发明人：KOENEMANN MARTIN; BOEHM ARNO; BIDLINGMAIER HERMANN; RIEGER REINHOLD; BLASCHKA PETER; REICHELT HELMUT; KRIEGER MATTHIAS
权利人:BASF AG
摘要:A process for preparing quaterrylene-3,4:13,14-tetracarboximides of the general formula I n nin whichn nR, R′ are each independently hydrogen or optionally substituted C 1 -C 30 -alkyl, C 5 -C 8 -cycloalkyl or aryl or hetaryl;n nwhich comprises reacting a perylene-3,4-dicarboximide of the general formula IIan n nin the presence of a base-stable, high-boiling, organic solvent and of an alkali metal base or alkaline earth metal base, with a perylene-3,4-dicarboximide of the general formula IIbn n nin which X is hydrogen, bromine or chlorine.

专利号:US-12187664-B2
优先权日:2019-10-29
标题:High purity 2-naphthylacetonitrile and method for producing same
发明人：NAGAHAMA MASAKI; OKADO DAIKI; TANIIKE HIROTSUGU
权利人:API CORP
摘要:High purity 2-naphthylacetonitrile with fewer impurities that is useful as a starting material or intermediate for the synthesis of various pharmaceutical products, agricultural chemicals, and chemical products, and a production method thereof. A high purity 2-naphthylacetonitrile having an HPLC purity of 2-naphthylacetonitrile of not less than 95 area %, and containing naphthalene compounds represented by the formulas (a)-(j) at a content of a predetermined area % or below. A method for producing high purity 2-naphthylacetonitrile.

专利号:US-2005026965-A1
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides

专利号:US-7358362-B2
优先权日:2004-01-23
标题:Method for the production of terylene-3,4:11,12-tetracarboxydiimides by direct synthesis
发明人：KOENEMANN MARTIN; BOEHM ARNO; HELFER WILLI; ROMEIS JUERGEN; QU JIANQIANG; MUELLEN KLAUS
权利人:BASF AG; MAX PLANCK GESELLSCHAFT
摘要:A process for preparing terylene-3,4:11,12-tetracarboximides I n nwhere the variables are each defined as follows:n R, R′ are each independently hydrogen; if desired substituted alkyl or cycloalkyl; R 1 is hydrogen or alkyl; R 2 is hydrogen; alkyl; if desired substituted aryl or hetaryl,n nby reacting a perylene-3,4-dicarboximide IIn n nin the presence of a base-stable, high-boiling organic solvent and of an alkali metal or alkaline earth metal base, with a naphthalene-1,8-dicarboximide IIIn n nin which X is hydrogen, bromine or chlorine.