CAS: 475488-23-4; 5-(3-(Benzyloxy)Phenyl)-7-(Trans-3-(Pyrrolidin-1-Ylmethyl)Cyclobutyl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine

主要参考文献

1: Zhou H, Rao J, Lin J, Yin B, Sheng H, Lin F, Zhang N, Yang L. The insulin- like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy. Oncol Rep. 2011 Jun;25(6):1565-71. doi: 10.3892/or.2011.1233. Epub 2011 Mar 23. 12(11 Pt 1):3532-40. doi: 10.1158/1078-0432.CCR-05-1778. 11(4):1563-71. doi: 10.1158/1078-0432.CCR-04-1544. 19(1):35-43. doi: 10.3727/096504010x12828372551821. 3(5):527-35. 32(2):199-206. doi: 10.3233/CBM-210016. 9(8):912. doi: 10.3390/biomedicines9080912. Erratum in: Biomedicines. 2022 Mar 22;10(4):
8: Yamagishi A, Ikeda Y, Ikeuchi M, Yuki R, Saito Y, Nakayama Y. Targeting Insulin-Like Growth Factor 1 Receptor Delays M-Phase Progression and Synergizes with Aurora B Inhibition to Suppress Cell Proliferation. Int J Mol Sci. 2020 Feb 5;21(3):1058. doi: 10.3390/ijms21031058.
9: Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M, Hideshima T, Chauhan D, Joseph M, Libermann TA, García-Echeverría C, Pearson MA, Hofmann F, Anderson KC, Kung AL. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell. 2004 Mar;5(3):221-30. doi: 10.1016/s1535-6108(04)00050-9. 137(6):871-9. doi: 10.1242/dev.043885.

合成参考文献

参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
参考文献:10.1016/j.canlet.2020.10.022
摘要:Catalano R, Giardino E, Treppiedi D, Mangili F, Morelli V, Elli FM, Serban AL, Luconi M, Mannelli M, Spada A, Arosio M, Mantovani G, Peverelli E. The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells. Cancer Lett. 2021 Jan 28;497():77–88. doi: 10.1016/j.canlet.2020.10.022.