CAS: 4355-15-1; 2,4-Dioxo-3-Azaspiro[5.5]Undecane-1,5-Dicarbonitrile
该化合物是一种环环环有机化合物,其特征是独特的环球结构,兼含氮和碳原子,该化合物有两个碳基(C=O)组和两个西诺(CN)组,有助于其在各种化学工艺中的再活性和潜在应用; 亚司伯里峰的存在表明,该物质在螺旋安排中含有氮原子,可影响其生物活动和稳定性; 双碳三联苯基功能表明,该物质可能参与核分裂的生物学反应,使其对合成有机化学具有兴趣; 此外,该化合物的结构复杂性可能适用于制药或农业化学应用,因为其生物特性经常被探索.
- 英文名称2,4-Dioxo-3-Azaspiro[5.5]Undecane-1,5-Dicarbonitrile
- 中文名称2,4-二氧代-3-氮杂螺[5.5]十一烷-1,5-二甲腈
- IUPAC名称2,4-dioxo-3-azaspiro[5.5]undecane-1,5-dicarbonitrile
- 其它别名2,4-Dioxo-3-Azaspiro[5.5]Undecane-1,5-Dicarbonitrile; 2,4-Dicyano-3,3-Pentamethyleneglutarimide; α,α-Dicyano-1,1-Cyclohexanediacetamide; Gabapentin Impurity 12; Gabapentin Impurity 1; 3-Azaspiro[5.5]Undecane-1,5-Dicarbonitrile, 2,4-Dioxo-; α,α'-Dicyano-1,1-Cyclohexanediacetamide; Gabapentin Impurity 1 (α,α’-Dicyano-1,1-Cyclohexanediacetamide)
- CAS编号4355-15-1
- MFCD编号:MFCD00023870
- EINECS号:224-428-4
- 分子式:C12H13N3O2分子量:231.26
- 产品CID: 1445864
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
上下游产品
cyclohexanone ethyl 2-cyanoacetate cyanoacetic acid amide ethyl 2-cyano-2-cyclohexylideneacetate 1,1-cyclohexanediacetic acid 1,1-cyclohexanediacetic acid anhydride 2,2'-(cyclohexane-1,1-diyl)bis(ethan-1-ol) cyclohexylidenedi-acetic acid diethyl ester合成工艺路线路线简述
- 合成目标产物 2,4-Dioxo-3-Azaspiro[5.5]Undecane-1,5-Dicarbonitrile 主要起始原料 Cyclohexanone And Ethyl Cyanoacetate And 2-Cyanoacetamide
- (文献来源)合成步骤主要原料 Cyclohexanone 和 Ethyl Cyanoacetate 和 2-Cyanoacetamide
📜Azanium;1,5-Dicyano-4-Oxo-3-Azaspiro[5.5]Undec-2-En-2-Olate置于硫酸体系中,用 水 作为反应溶剂,化学反应 2.0H,以98.94%的收率获得产物2,4-二氧代-3-氮杂螺[5.5]十一烷-1,5-二甲腈
参考文献:一种2,4-二氧-3-氮杂-螺[5,5]十一烷-1,5-二腈的制备方法
标题:一种2,4-二氧-3-氮杂-螺[5,5]十一烷-1,5-二腈的制备方法
摘要:本发明提供一种2,4‑二氧‑3‑氮杂‑螺[5,5]十一烷‑1,5‑二腈的制备方法,包括以下步骤:将氨甲醇溶液滴加至环己酮和氰乙酸甲酯的混合溶液中,保温反应,得2,4‑二氧‑3‑氮杂‑螺[5,5]十一烷‑1,5‑二腈铵盐溶液;然后加入水混合均匀,滴加硫酸溶液,保温反应,分离,洗涤,得2,4‑二氧‑3‑氮杂‑螺[5,5]十一烷‑1,5‑二腈.本发明提供的2,4‑二氧‑3‑氮杂‑螺[5,5]十一烷‑1,5‑二腈的制备方法,工艺简单,能耗低,副反应少,产品收率可达到98.5%以上,产品中氨氮的含量低于0.3%,氰乙酸甲酯的单耗为0.85~1.1T/t,适合大规模工业生产.
海关参考信息
- 2912110000-甲醛
2912120000-乙醛
2924199090-其他无环酰胺
2926909090-其他腈基化合物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7759517-B2
优先权日:2004-06-24
标 题:Process for the preparation of gabapentin
发明人：VILLA MARCO; PAIOCCHI MAURIZIO; ARRIGHI KATIUSCIA; CORCELLA FRANCESCO; CANNATA VINCENZO; SORIATO GIORGIO; VERZINI MASSIMO
权利人:ZACH SYSTEM SPA
摘要:The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of α, -diaminocarbonyl-β,β-pentamethylene glutarimide.
专利号:US-7381823-B2
优先权日:2004-03-17
标 题 :Process for preparing cyclohexanediacetic acid monoamide
发明人：DANIELI BRUNO; DELOGU PIETRO; ROSA SABRINA DE; FUGAZZA LORENZA
权利人:SERICHIM S R L
摘要:A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is convertible, under mild reaction conditions, into cyclohexanediacetic acid monoamide.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Synthesis Of 4-Substituted 3,5-Dicyano-2,6-Piperidinediones Using Lithium Nitride As A Convenient Source Of Ammonia作者:Li Qiang Wu,Chunguang Yang,Liming Yang,Lijuan Yang
摘要:A Simple And Efficient One-Pot Synthesis Of 4-Substituted-3,5-Dicyano-2,6-Piperidinediones Was Achieved In Good Yields Via The Three-Component Reaction Of Aldehyde Or Ketone, Ethyl Cyanoacetate, Lithium Nitride (Li 3 N) As A Convenient Source Of Ammonia In Meoh.
合成参考文献
摘要:Biomedica Biochimica Acta., 44(795), 1985 []
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