CAS: 4333-20-4; 5-Isopropyl-3-Phenyl-2-Thioxoimidazolidin-4-One

该化合物是谷碱的衍生物,主要用于Edman降解,用于蛋白序列.作为硫代丁胺酯化合物,它通过苯乙酰胺与N终点谷素残留物的反应形成,促成分级氨基酸分析.它的稳定性和不同的色谱特性有利于在HPLC或质谱测量应用中准确识别和量化.PTH-valine因其在重复降解周期中的可靠性而受到重视,确保准确的序列确定.该化合物的高度纯度和一贯性使得它成为蛋白质学研究中的关键再剂,特别是用于定性基结构和转基因后修改.建议在水下进行适当处理以保持完整性.

英文名称5-Isopropyl-3-Phenyl-2-Thioxoimidazolidin-4-One
中文名称5-异丙基-3-苯基-2-硫代咪唑烷-4-酮
IUPAC名称5-isopropyl-3-phenyl-2-thioxoimidazolidin-4-one
其它别名苯基硫代乙内酰脲-缬氨酸; Pth-Valine
CAS编号4333-20-4
MFCD编号:MFCD06858300
分子式:C12H14N2OS分子量:234.32
产品CID: 1444498
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: HEIKHJHSVLQGGN-UHFFFAOYSA-N
InChI=1S/C12H14N2OS/c1-8(2)10-11(15)14(12(16)13-10)9-6-4-3-5-7-9/h3-8,10H,1-2H3,(H,13,16)
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数2.0

MSDS等安全信息

GHS符号GHS06
警示词Danger
危险描述H301-H311-H331
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
危险等级6.1
UN编号2811.0
包装等级Ⅲ
WGK Germany3

上下游产品

CAS号433286-75-0 phenylthi°Carba... | CAS号13734-41-3 B°C-L-缬氨酸 | CAS号103-72-0 异硫氰酸苯酯 | CAS号516-06-3 DL-缬氨酸

合成工艺路线路线简述

📜N-Boc-Dl-缬氨酸置于4-二甲氨基吡啶,二乙胺,N,N-二异丙基乙胺,N,N'-二环己基碳二亚胺体系中,用甲醇,二氯甲烷,乙腈作为反应溶剂,化学反应 27.25H,反应生成苯基硫代乙内酰脲-缬氨酸
参考文献:Microwave-Assisted Synthesis Of 3,5-Disubstituted Thiohydantoins Using Functional Ionic Liquid As Soluble Support
标题:Microwave-Assisted Synthesis Of 3,5-Disubstituted Thiohydantoins Using Functional Ionic Liquid As Soluble Support
摘要:A New Approach For The Syntheses Of 3,5-Disubstituted Thiohydantoins Was Described Using Functionalized Ionic Liquid As Soluble Support. The Products Were Obtained In Good Yields And Purities After Cyclization-Cleavage From The Ionic-Liquid-Supported Under Microwave Irradiation,The Ionic-Liquid-Supported Species Can There Be Purified From The Reaction Mixture By Simple Washing,And No Chromatographic Purification Were Needed During The Synthesis.
DOI:10.3987/com-10-12086