CAS: 41679-15-6; (S)-4-Hydroxy-3-Hydroxymethylphenylalanine

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salicylic alcohol 2-oxo-propionic acid (S)-N-benzyloxycarbonyl-4-hydroxy-3-hydroxymethylphenylalanine benzyl (S)-4-(4H-1,3-benzodioxin-6-ylmethyl)-5-oxo-1,3-oxazolane-3-carboxylate

📜N-苄氧羰基-L-酪氨酸置于三氯化硼,碳酸氢钠,对甲苯磺酸体系中,用 甲醇,二氯甲烷,水,甲苯 作为反应溶剂,化学反应 5.17H,反应生成 3-(羟甲基)-L-酪氨酸
参考文献:A Convenient Two Step Transformation Of Tyrosine Into The Antihypertensive Amino Acid (S)-4-Hydroxy-3-Hydroxymethylphenylalanine
标题:A Convenient Two Step Transformation Of Tyrosine Into The Antihypertensive Amino Acid (S)-4-Hydroxy-3-Hydroxymethylphenylalanine
摘要:Treatment Of Tyrosine With Paraformaldehyde And Catalytic Amounts Of P-Toluenesulfonic Acid,At Reflux In Toluene,Directly Generates Benzyl (S)-4-(4H-1,3-Benzodioxin-6-Ylmethyl)-5-Oxo-1,3-Oxazolane-3-Carboxylate,Which On Treatment With Boron Trichloride In Dichloromethane,Affords (S)-4-Hydroxy-3-Hydroxymethylphenylalanine. (C) 2004 Published By Elsevier Ltd.
DOI:10.1016/j.Tetasy.2004.02.031