CAS: 36822-11-4; 2-Mercapto-6-Phenylpyrimidin-4-Ol

相似化合物

175202-77-4 375834-47-2 1239848-73-7

上下游产品

ammonium thi°Cyanate ethyl 3-oxo-3-phenylpropionate thiourea 5-benzoyl-2,2-dimethyl-1,3-dioxane-4,6-dione 2-methylthio-6-phenyl-3,4-dihydropyrimidin-4-one H-pyrimidine-2-thione6-phenyl-3,4-dihydro-1H-pyrimidine-2-thione 6-phenyluracil 6-phenylpyrimidine-2,4(1H,3H)-dithione

📜苯甲酸甲酯置于sodium Ethanolate,Sodium Hydride体系中,用 乙醇,甲苯,Mineral Oil 作为反应溶剂,化学反应 20.5H,反应生成 6-苯基-2-硫尿嘧啶
参考文献:Hts,然后进行基于NMR的反向筛选.发现和优化作为黄嘌呤氧化酶可逆和竞争性抑制剂的嘧啶酮
标题:Hts,然后进行基于NMR的反向筛选.发现和优化作为黄嘌呤氧化酶可逆和竞争性抑制剂的嘧啶酮
摘要:描述了新型,非嘌呤的黄嘌呤氧化酶抑制剂的鉴定.经过高通量筛选活动后,基于NMR的反筛选用于区分活性物,这些活性物以可逆方式与xo相互作用,与分析伪像分离.该方法将嘧啶酮1鉴定为可逆的竞争性抑制剂,具有非常好的铅样性质.导致先头运动获得化合物41,一种hxo的纳摩尔抑制剂,口服给药后在高尿酸血症大鼠模型中具有功效.
DOI:10.1016/j.Bmcl.2014.01.050

专利信息

专利号:US-RE37623-E
优先权日:1993-11-02
标题:Enzyme inhibitors, their synthesis, and methods for use
发明人：EL KOUNI MAHMOUD H; NAGUIB FARDOS N M; SCHINAZI RAYMOND F
权利人:EL KOUNI MAHMOUD H; NAGUIB FARDOS N M; SCHINAZI RAYMOND F
摘要:Novel compounds are provided that are effective to inhibit the activity of DHUDase or UrdPase. Such compounds have the general formula n where X is S or Se; Y is H, I, F, Cl, Br, methoxy, benzyl, selenenylphenyl, or thiophenyl, and R 1 is H or an acyclo tail having the general formula n where R 2 is H, CH 2 OH or CH 2 NH 2 ; R 3 is OH, NH 2 , or OCOCH 2 CH 2 CO 2 H; and R 4 is O, S, or CH 2 . n The compounds can be used in pharmaceutical compositions, along with various chemotherapeutic agents to increase the efficacy of the treatment. These compounds can also be used in methods of treating patients by coadministering or sequentially administering the enzyme inhibiting compounds with a chemotherapeutic agent effective to treat cancers, or viral, fungal, bacterial, or parasitic infections. The compounds have further utility in enhancing imaging. Further, they can be administered alone to prevent and/or treat disorders of pyrimidine catabolism and other physiological disorders.

专利号:US-3890321-A
优先权日:1971-09-20
标题 :6-aryl-5-ethyl-pyrimidin-4-ol compounds useful as intermediates and bronchodilators
发明人：DEANGELIS GERALD GEORGE; HESS HANS-JURGEN ERNST
权利人:PFIZER
摘要:4-Hydroxy-5-ethyl-6-arylpyrimidines are useful intermediates leading to the synthesis of 4-amino-5-ethyl-6-arylpyrimidines, inhibitors of platelet aggregation and bronchodilators. 4Hydroxy-5-ethyl-6-phenylpyrimidine is also useful as a bronchodilator.

专利号:CN-108409635-A
优先权日:2018-05-10
标题:A kind of carbazole fluorescent thymine drug labeling reagent, synthesis and application