专利号:US-11459549-B2 优先权日:2018-05-10 标 题:Method for biocatalytic synthesis of Sitagliptin and intermediate thereof 发明人:WU FAHAO; YANG WEN; LI GANG; SHI HONGWEI; GAO YANGZHE; LIU LILI; YUAN ZHIFA 权利人:CHINA FORTUNE WAY COMPANY; NANJING REDWOOD FINE CHEMICAL CO LTD 摘要:Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catalyzing conversion of a compound of Formula (I) to a compound of Formula (II), a nucleic acid encoding the polypeptide, a vector and a cell comprising the nucleic acid. In addition, also provided are a method for producing a compound of Formula (II) and Sitagliptin by using the polypeptide and the compound of Formula (I), and a method for preparing the polypeptide.
专利号:US-2021123080-A1 优先权日:2018-05-10 标题:Method for biocatalytic synthesis of sitagliptin and intermediate thereof
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专利号:CN-112424171-B 优先权日:2018-05-10 标题 :A kind of method of biocatalytic synthesis of sitagliptin and its intermediate
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