CAS: 304858-65-9; 2-Amino-4-Bromobenzonitrile

上下游产品

CAS号1885-29-6 2-氨基苯甲腈 | CAS号112253-70-0 2-氨基-4-溴苯甲酰胺 | CAS号39859-36-4 2-苯甲酰-4-溴苯胺 | CAS号21419-48-7 6-溴喹唑啉-4-胺

2-氨基苯甲腈置于n-溴代丁二酰亚胺(Nbs),Lithium Perchlorate,Silica Gel体系中,用 二氯甲烷 用作溶剂,化学反应 0.08H,以95%的收率获得2-氨基-4-溴苯腈
参考文献:高氯酸锂分散在硅胶上在n-溴代琥珀酰亚胺溴化芳香族化合物中的有趣作用
标题:高氯酸锂分散在硅胶上在n-溴代琥珀酰亚胺溴化芳香族化合物中的有趣作用
摘要:通过在室温下将 N-溴代琥珀酰亚胺和芳族化合物在二氧化硅表面混合,开发了一种方便有效的亲电芳族溴化方法.
Doi:10.1139/v05-001

专利信息

专利号:US-9073900-B2
优先权日:2013-10-02
标题:Dihydroquinone derivatives of piperidine and piperazine
发明人：ULLAH NISAR
权利人:UNIV KING FAHD PET & MINERALS; KING ABDULAZIZ CITY SCI & TECH
摘要:The dihydroquinone derivatives of piperidine and piperazine are 7-piperazinyl and 7-piperadinyl-3,4-dihydroquinazolin-2(1H)-ones that exhibit D 2 and 5-HT 1A receptor binding affinities, making them suitable for use as the active ingredient of pharmaceuticals for the treatment of schizophrenia. The derivatives have the general formula: n nwhere X is carbon or nitrogen and R is a group selected from a through f having the formula:n n nor a pharmaceutically acceptable salt thereof. The piperazine compounds are prepared by condensing 4-bromo-2-nitro-benzonitrile with 1-Boc-piperazine (1-tert-butoxycarbonyl-piperazine) to form an intermediate that is converted to a piperazinyl-3,4-dihydroquinazolin-2(1H)-one. Subsequent reductive amination with the biarylaldehydes a through f completes the synthesis of the 7-piperadinyl-3,4-dihydroquinazolin-2(1H)-ones. The piperadinyl compounds are prepared from tert-butyl-4-(2-oxo-1,2,3,4-tetradihydroquinazolin-7-yl)piperidine-1-carboxylate, which is converted to 7-(piperidin-4-yl)-3,4-dihyroquinazolin-2(1H)-one. Subsequent reductive amination with the biarylaldehydes a through f completes the synthesis of the 7-piperidinyl-3,4-dihydroquinazolin-2(1H)-ones.