CAS: 205526-31-4; (R)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(3,4,5-Trifluorophenyl)Propanoic Acid

该化合物是氨酸苯丙氨的衍生物,用氟氧基碳基(Fmoc)保护组和三氟甲基替代物加以修改.该化合物的特点是其独特的结构,包括氟基基化合物,该化合物的稳定性和溶液溶性增强有机溶剂的稳定性和溶性,使其在peptide合成中有用.三氟基甲基甲基化合物的特性,如溶性点,溶解性,可影响化合物的再活动和与生物系统的互动性.氟基-D-Tyr(3,5-F3)-OHS,通常用于固基甲基合成,该化合物组作为氨基化合物的一个临时保护组,允许依次添加氨基酸.其特性,例如熔点,溶性,溶性,可溶性,能和再感化等,其结构应用特性也影响着该化学领域的重要.

英文名称(R)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(3,4,5-Trifluorophenyl)Propanoic Acid
中文名称(R)-2-((((9H-芴-9-基)甲氧基)羰基)氨基)-3-(3,4,5-三氟丙基)丙酸
IUPAC名称(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(3,4,5-trifluorophenyl)propanoic acid
其它别名Fmoc-D-3,4,5-三氟苯丙氨酸; Fmoc-D-Phe(M,P-F3)-Oh
CAS编号205526-31-4
MFCD编号:MFCD00797584
分子式:C24H18F3NO4分子量:441.4
产品CID: 1041532
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: VNMUACAZWGQRRL-OAQYLSRUSA-N
InChI=1S/C24H18F3NO4/c25-19-9-13(10-20(26)22(19)27)11-21(23(29)30)28-24(31)32-12-18-16-7-3-1-5-14(16)15-6-2-4-8-17(15)18/h1-10,18,21H,11-12H2,(H,28,31)(H,29,30)/t21-/m1/s
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数6.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H315-H319-H335
防范说明P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
危险等级IRRITANT
危险品标志Xi

上下游产品

1,2,3-trifluoro-5-iodobenzene (fluorenylmethoxy)carbonyl chloride

合成工艺路线路线简述

📜Rac-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(3,4,5-Trifluorophenyl)Propanoic Acid置于chiral Sfc Column体系中,用43.3 %的收率获得fmoc-L-3,4,5-三氟苯基丙氨酸
参考文献: Macrocylic Immunomodulators[fr] Immunomodulateurs Macrocycliques
标题: Macrocylic Immunomodulators[fr] Immunomodulateurs Macrocycliques
摘要:In Accordance With The Present Disclosure,Macrocyclic Compounds Have Been Discovered That Bind To Pd-1 And Are Capable Of Inhibiting The Interaction Of Pd-1 And Pd-L1. These Macrocyclic Compounds Exhibitin Vitroimmunomodulatory Efficacy Thus Making Them Therapeutic Candidates For The Treatment Of Various Diseases Including Cancer And Infectious Diseases.