CAS: 190906-92-4; Tert-Butyl 2-Methyl-4-Oxopiperidine-1-Carboxylate

该化合物是有机合成的多用途中间体,对于建造以管道为基础的框架特别有用,其受泡沫保护的安咪功能增强了稳定性,便利了在标准条件下的处理和储存;四级基酮组为进一步衍生,促进制药和农用化学应用提供了一个反应场所;三丁基酯能确保与多种反应条件,包括基本和核分裂生物环境兼容;该化合物由于其结构灵活性和可靠的再活性特征,在药用化学中特别有助于生物活性分子的开发;为满足严格的合成需求,通常具备高纯度的品位.

结构式图片

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ECHA物质C&L通报

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合成工艺路线路线简述

    N-Boc-7-Methyl-1,4-Dioxa-8-Azaspiro<4.5>Decane置于对甲苯磺酸体系中,用 丙酮 用作溶剂,以48%的收率获得1-叔丁氧羰基-2-甲基-哌啶酮
    参考文献:Ep1375482
    标题:Ep1375482

    海关参考信息

    专利信息


    专利号:WO-0146142-A1
    优先权日:1999-12-20
    标题:A process for the regioselective synthesis of 2,2-dialkyl-4-substituted piperidines
    发明人:HEATH PERRY CLARK
    权利人:LILLY CO ELI; HEATH PERRY CLARK
    摘要:The present invention provides a process for preparing a compound of formula (I): wherein R?1 and R2¿ each independently represent C¿1?-C4 alkyl; and X represents an alkyl, alkenyl, cycloalkyl, aryl, substituted aryl, heterocycle, or substituted heterocycle, comprising treating a compound of formula (II): wherein Q represents Cl or Br, with a suitable base followed by addition of a suitable Lewis acid and addition of a compound of formula R?-M+¿ wherein M+ is a suitable cation.

    专利号:US-2024400552-A1
    优先权日:2016-11-11
    标题 :Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-11622968-B2
    优先权日:2011-03-08
    标 题:Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-11034690-B2
    优先权日:2016-11-11
    标 题:Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-9809591-B2
    优先权日:2011-03-08
    标题 :Heterocyclic modulators of lipid synthesis
    发明人:OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
    权利人:3-V BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

    专利号:EP-1242377-A1
    优先权日:1999-12-20
    标题:A process for the regioselective synthesis of 2,2-dialkyl-4-substituted piperidines
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