CAS: 18269-64-2; Trimethylsilyl Crotonate

上下游产品

2-butenoic acid chloro-trimethyl-silane 3-(trimethylsilyl)-2-oxazolidinone trimethylsilylazide1,1-bis(trimethylsilyloxy)-buta-1,3-diene crotonyl bromide 3-(2,2-Bis-trimethylsilanyloxy-vinyl)-2,2-diphenyl-cyclobutanone chloro-trimethyl-silane

📜三甲基氯硅烷,巴豆酸置于吡啶体系中,用 乙醚 用作溶剂,化学反应 3.0H,以62%的收率获得三甲基甲硅烷丁烯酸酯
参考文献:Cyanoquinoline Derivatives
标题:Cyanoquinoline Derivatives
摘要:公开了一种公式i的化合物,其立体异构体,其顺反异构体,其互变异构体,或它们的混合物,或其药物可接受的盐,其溶剂化物或其前药,其中r1,R2,R3和r4各自如在本申请中定义.

专利信息

专利号:US-9242965-B2
优先权日:2013-12-31
标题:Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
发明人：ZHENG JUNCHENG; DENG DA; LV GUANGHUA; YAN JUN; BRANDENBURG JOERG; KROEBER JUTTA; SCHOLZ ULRICH
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I n nwherein R 1 and R 2 independently denote C 1-3 -alkyl groups and X − denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

专利号:US-7126025-B2
优先权日:2003-01-21
标 题 :Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
发明人：CONSIDINE JOHN LEO; DAIGNEAULT SYLVAIN; CHEW WARREN; IERA SILVIO; DUNCAN SCOTT MASON; REN JIANXIN
权利人:WYETH CORP
摘要:This invention provides a compound of Formula (I): n nwhereinn S 1 and S 2 are each independently, hydrogen, alkyl, alkenyl, alkynyl, aralkyl, substituted or unsubstituted aryl, and S 1 and S 2 together with the nitrogen to which they are attached form a nitrogen containing heteroaryl and a pharmaceutically acceptable salt thereof; a method of preparing the compound of Formula (I), and use of the compound of Formula (I) in the preparation of 3-cyano quinolines.

专利号:US-2004162442-A1
优先权日:2003-01-21
标 题 :Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines

专利号:CA-2514550-A1
优先权日:2003-01-21
标题:Synthesis of 4amino-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines

专利号:WO-2004066919-A2
优先权日:2003-01-21
标 题:Synthesis of 4amino-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines

专利号:TW-200418763-A
优先权日:2003-01-21
标 题 :Synthesis of 4-amino-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines